Posted on February 6th, 2009 by
Two studies evaluated factors that were linked with prostate cancer recurrence, metastasis (spread), or death. If confirmed, the results of these studies may help healthcare professional identify men with life-threatening prostate cancer.
The first study evaluated the rate of prostate-specific antigen (PSA) increase many years before prostate cancer diagnosis. Prostate-specific antigens are proteins that are normally shed by the prostate into the bloodstream. Elevated PSA levels may indicate the presence of prostate cancer and response to therapy. A question that remains uncertain, however, is whether the rate of PSA increase can be used to identify potentially life-threatening prostate cancer during a period when the cancer is still curable.
To address this question, researchers evaluated information from the Baltimore Longitudinal Study on Aging. The researchers evaluated PSA histories in three groups of men: men without a diagnosis of prostate cancer; men who had died of prostate cancer; and men who had been diagnosed with prostate cancer but were still alive or had died of another cause.
The researchers conclude that “PSA velocity [rate of increase] may help identify men with life-threatening prostate cancer during a period when their PSA levels are associated with the presence of curable disease.”
The second study assessed levels of a particular protein (zinc-alpha2-glycoprotein, or AZGP1) in early-stage prostate cancers removed by prostatectomy. The researchers evaluated whether levels of this protein were linked with the likelihood cancer recurrence, metastasis, or death.
If confirmed, these results suggest that AZGP1 levels in cancer tissue removed by prostatectomy may provide valuable information regarding a patient’s prognosis and need for aggressive treatment. An advantage of this marker is that it could be assessed early—immediately after the patient undergoes surgery for prostate cancer.
These and other similar studies are building our understanding of how particular prostate cancers are likely to behave. Eventually, this may allow for more individualized prostate cancer treatment.
 Henshall S, Horvath L, Quinn D, et al. Zinc-alpha2-glycoprotein Expression as a Predictor of Metastatic Prostate Cancer Following Radical Prostatectomy. Journal of the National Cancer Institute. 2006; 98:1420-1424.
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