Posted on March 8th, 2009 by
Among postmenopausal women with hormone receptor-positive, HER2-positive, metastatic breast cancer, the combination of Tykerb® (lapatinib) and Femara® (letrozole) resulted in longer progression-free survival than treatment with Femara alone. These results were presented at the 2008 San Antonio Breast Cancer Symposium.
Each year, more than 180,000 U.S. women are diagnosed with breast cancer. Many of these breast cancers will be hormone receptor-positive, meaning that they are stimulated to grow by the circulating female hormones estrogen and/or progesterone.
Treatment of hormone receptor-positive breast cancer often involves hormonal therapies that suppress or block the action of estrogen. These therapies include tamoxifen as well as agents known as aromatase inhibitors. Tamoxifen acts by blocking estrogen receptors, whereas aromatase inhibitors suppress the production of estrogen in postmenopausal women.
Femara is an aromatase inhibitor that has been shown to improve outcomes among postmenopausal women with hormone receptor-positive or hormone receptor-unknown breast cancer.
Tykerb is a drug that targets two related proteins that often function abnormally in breast cancer cells-HER2 and EGFR. Approximately 20-25% of breast cancers overexpress the HER2 protein; these cancers are referred to as HER2-positive.
To evaluate the combination of Tykerb and Femara in the initial treatment of hormone receptor-positive, metastatic breast cancer, researchers conducted a Phase III clinical trial among 1,286 postmenopausal women. A total of 219 of the study participants were HER2-positive.
Study participants received treatment with Femara alone or Femara plus Tykerb.
This study suggests that compared with treatment with Femara alone, the combination of Tykerb and Femara delays cancer progression among women with HER2-positive, hormone receptor-positive, metastatic breast cancer.
Reference: Johnston S, et al. Lapatinib combined with letrozole vs. letrozole alone for front line postmenopausal hormone receptor positive (HR+) metastatic breast cancer (MBC): first results from the EGF30008 trial. Proceedings from the San Antonio Breast Cancer Symposium 2008. Abstract 46.
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