Posted on June 15th, 2010 by
The combination of vandetanib plus Taxotere resulted in longer survival without cancer progression than Taxotere alone among patients with previously-treated non–small cell lung cancer (NSCLC). These findings were recently published in the journal The Lancet Oncology.
Lung cancer causes more cancer-related deaths in the United States than the next three most deadly cancers combined. Non–small cell lung cancer (NSCLC) is the most common type of lung cancer, comprising approximately 75–80% of all lung cancers.
Because many lung cancer patients experience poor treatment outcomes, researchers continue to explore new approaches to treatment, such as new targeted therapies. A targeted therapy is one that is designed to treat only the cancer cells and minimize damage to normal, healthy cells. Cancer treatments that “target” cancer cells may offer the advantage of reduced treatment-related side effects and improved outcomes.
Vandetanib is an investigational targeted therapy that is taken orally. It targets cell signaling pathways that influence tumor growth and spread, specifically those that involve the vascular endothelial growth factor receptor (VEGFR) and the epidermal growth factor receptor (EGFR). Previous studies have indicated that the combination of vandetanib plus Taxotere may result in longer survival without cancer progression than Taxotere alone among patients with previously-treated NSCLC. Based on these results, this larger Phase III study was designed to further define the role of vandetanib combined with Taxotere in NSCLC.
In this double-blind Phase III study, researchers evaluated 1,392 Stage IIIB-IV NSCLC patients who had progressed following initial treatment. Patients were randomized to receive either vandetanib plus Taxotere or a placebo plus Taxotere.
The researchers concluded that the combination of vandetanib plus Taxotere resulted in longer survival without cancer progression than Taxotere alone among patients with previously-treated NSCLC. Slowing disease progression is associated with better control of the symptoms caused by lung cancer. In addition the researchers indicated that “to the best of our knowledge, vandetanib is the first oral targeted therapy in phase 3 trials to show significant evidence of additional efficacy when added to standard chemotherapy, in patients with previously treated NSCLC.”
 Heymach JV, Johnson BE, Prager D et al. Randomized, placebo-controlled Phase II study of vandetanib plus docetaxel in previously treated non-small cell lung cancer. Journal of Clinical Oncology. 2007;4270-4277.
Tags: UNM CC Features
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