Posted on June 28th, 2010 by
Class: Supportive care
Generic Name: Granisetron (gra NIS e tron) transdermal system
Trade Name: Sancuso®
For which conditions is this drug approved? Sancuso is FDA approved for the prevention of nausea and vomiting in patients receiving moderately and/or highly emetogenic (vomit-inducing) chemotherapy for up to 5 consecutive days. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.
What is the mechanism of action? Sancuso belongs to a class of drugs called antiemetics. Antiemetics help prevent nausea and vomiting caused by chemotherapy. Sancuso produces its anti-nausea effects by binding to a receptor called 5-HT3. This binding blocks pathways that normally trigger nausea or vomiting.
How is Sancuso typically given (administered)? Sancuso is administered as a patch that sticks to the skin. The patch continuously delivers granisetron over a several-day period. The patch is applied 24 to 48 hours before chemotherapy begins.
Side effects of treatment with Sancuso are uncommon, and include the following:
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
Are there any special precautions patients should be aware of before starting treatment?
When should patients notify their physician?
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
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