Posted on June 30th, 2010 by
Class: Biological Therapy
Generic Name: Dasatinib
Trade Name: Sprycel®
How is this drug used? Sprycel is used for the treatment of adults with newly diagnosed, Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase, as well as adults with Ph+ CML who are resistant to or intolerant of prior therapy including Gleevec® (imatinib). Sprycel is also approved for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance or intolerance to prior therapy.
What is the mechanism of action? Sprycel reduces the activity of one or more proteins that are responsible for the uncontrolled growth of leukemia cells in patients with Ph+ CML or Ph+ ALL.
How is Sprycel given (administered)? Sprycel is administered orally in the form of a tablet. The dose depends on the type and stage of leukemia. Sprycel can be taken with or without a meal. Tablets should be swallowed whole.
How are patients monitored? Patients will usually have scheduled meetings with their healthcare provider while they are being treated with Sprycel. Typically, blood will be drawn to check levels of blood cells and to monitor functions of some organ systems. Patients may also undergo physical examinations, scans or other measures to assess side effects and response to therapy.
What are some of the potentially serious side effects of treatment with Sprycel?
What are some of the other common side effects of treatment with Sprycel ?
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
Are there any special precautions patients should be aware of before starting treatment?
When should patients notify their physician?
Tell your doctor if you experience any side effects that bother you or don’t go away. Also watch for and immediately report symptoms of potentially serious side effects such as infection (fever), bleeding (unusual bleeding or bruising of the skin, bright red or dark tar-like stools, a decrease in level of consciousness, headache, or change in speech), fluid retention (swelling all over your body, weight gain, shortness of breath and cough), and pulmonary arterial hypertension (shortness of breath, tiredness, or fluid retention).
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
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