Posted on February 1st, 2012 by
Class: Biological Therapy
Generic Name: axitinib
Trade Name: Inlyta®
How is this drug used? Inlyta is FDA approved for the treatment of advanced renal cell carcinoma (kidney cancer) after one prior drug treatment has not worked. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than for which it is approved may wish to discuss this issue with their physician.
What is the mechanism of action? Inlyta is a type of drug known as a kinase inhibitor. It works by blocking certain proteins that play a role in cancer growth
How is Inlyta typically given (administered)? Inlyta is taken orally (by mouth), typically twice per day.
How are patients typically monitored? Patients will usually have scheduled meetings with their healthcare provider while they are being treated with Inlyta. Typically, blood will be drawn to check levels of blood cells and to monitor functions of some organ systems. Physical examinations, scans or other measures may also be utilized to assess side effects and response to therapy.
What are the most common side effects of treatment with Inlyta?
What are some of the less common side effects to be aware of?
This is not a complete list of side effects. Some patients may experience other side effects that are not listed above. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
Are there any special precautions patients should be aware of before starting treatment?
When should patients notify their physician?
Tell your doctor if you experience any side effects that bother you or don’t go away. Also call if you notice signs of thyroid problems (e.g. persistent tiredness, feeling hot or cold, weight gain or loss, voice deepening, hair loss, or muscle cramps), signs of a blood clot (e.g. chest pain or pressure; pain in arms, back, neck, or jaw; shortness of breath; numbness or weakness on one side of the body; trouble talking; headache; vision problems), signs of unusual bleeding (e.g. bleeding that is heavy or persistent, pink or brown urine, red or black stools, unusual bruising, coughing up or vomiting blood, unexpected pain or swelling; headache or dizziness), signs of a gastrointestinal tear (e.g. severe stomach pain, bloody vomit, red or black stools), or signs of brain problems (e.g headache, seizure, weakness, confusion, high blood pressure, blindness or change in vision, problems thinking).
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug by healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics, and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
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