Posted on March 6th, 2012 by
Among patients with intermediate- or high-risk myelofibrosis, Jakafi™ (ruxolitinib) reduced spleen size, relieved symptoms, and improved overall survival. The results of this Phase III clinical trial were published in the New England Journal of Medicine.
Myelofibrosis is a chronic disease characterized by abnormal blood cell development and the formation of scar tissue in the bone marrow. Symptoms of myelofibrosis can include fatigue, shortness of breath, abdominal discomfort, pain under the ribs, feeling full, muscle and bone pain, itching, and night sweats. Most patients with myelofibrosis have an enlarged spleen, and many have an enlarged liver.
For people who are experiencing symptoms from myelofibrosis, previous approaches to treatment have included blood transfusions, drug therapy, radiation therapy, surgery to remove the spleen, or stem cell transplantation.
Jakafi was the first drug approved specifically for myelofibrosis. It is taken orally and inhibits two enzymes—JAK1 and JAK2—that contribute to myelofibrosis.
The current study enrolled 309 patients from 89 centers in theUnited States. The patients had intermediate-2 or high-risk myelofibrosis. Half received Jakafi and half received a placebo.
These results demonstrate that Jakafi improves both quality and duration of life among patients with intermediate- or high-risk myelofibrosis. This is an important new treatment option for patients with this condition.
Reference: Verstovsek S, MesaRA, Gotlib J et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. New England Journal of Medicine. 2012;366:799-807.
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