Posted on May 18th, 2015 by
Class: Biological Therapy
Generic Name: axitinib
Trade Name: Inlyta®
For which conditions is this drug approved? Inlyta is approved for the treatment of advanced renal cell carcinoma (kidney cancer) when prior treatment hasn’t worked.
What is the mechanism of action? Inlyta is a kinase inhibitor. These drugs work by blocking the action of enzymes called kinases, which are involved in many cell functions, including cell signaling, growth, and division. These enzymes may be too active or found at high levels in some types of cancer cells, and blocking them may help keep cancer cells from growing.
How is Inlyta typically given (administered)? Inlyta is given orally, as a tablet.
How are patients typically monitored? While you are taking Inlyta, your doctor will monitor your blood pressure, thyroid function, liver function, and check you for a condition called proteinuria in which your urine contains an abnormal amount of protein.
What are the common (occur in 30% or more of patients) side effects of treatment with Inlyta?
What are the less common (occur in 10% to 29% of patients) side effects of treatment with Inlyta?
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
Are there any special precautions patients should be aware of before starting treatment?
When should patients notify their physician? Tell your doctor if you have any side effect that bothers you or that does not go away, including:
Tell your doctor if you have signs of problems with blood clots in your veins or arteries. Get emergency help is you experience any of the following symptoms:
Tell your doctor if you have signs of bleeding. Get medical help right away if you experience:
Tell your doctor if you have signs of a tear in your stomach or intestinal wall (perforation). Get medical help right away if you get the following symptoms:
Call your doctor right away if you have signs of a condition called reversible posterior leukoencephalopathy syndrome (RPLS). Signs of RPLS include:
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
Last updated on 09/16.
Important Limitations of Use
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