Posted on May 26th, 2015 by
Class: Biological Therapy
Generic Name: Olaparib
Trade Name: Lynparza™
For which conditions is this drug approved? Lynparza is used treat women with advanced ovarian cancer who have: a) received previous treatment with three or more prior chemotherapy medicines or a combination of chemotherapy medicines; and b) have a certain type of abnormal inherited BRCA gene.
What is the mechanism of action? Lynparza is a targeted drug called a PARP inhibitor. The PARP enzyme plays a role in DNA repair, including the repair of DNA damage from chemotherapy. Drugs that inhibit this enzyme may contribute to cancer cell death and increased sensitivity to chemotherapy.
How is Lynparza typically given (administered)? Lynparza is given as a capsule. You’ll take it two times a day.
How are patients typically monitored? Before you start taking Lynparza and while you’re on treatment, your doctor will check your blood cell counts to make sure you’re not developing a serious bone marrow disorder or cancer. Your doctor will also regularly check your lung function and monitor you for inflammation in your lung tissue.
What are the common (occur in 30% or more of patients) side effects of treatment with Lynparza?
What are the less common (occur in 10% to 29% of patients) side effects of treatment with Lynparza?
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
Are there any special precautions patients should be aware of before starting treatment?
When should patients notify their physician?
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
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