Posted on September 29th, 2015 by
Generic Name: Trifluridine and Tipiracil
Trade Name: Lonsurf®
For which conditions is this drug approved? Lonsurf is approved for the treatment of adult patients with colon or rectal cancer that has spread to other parts of the body and who have been previously treated or cannot receive certain chemotherapy medicines.
What is the mechanism of action? The two active drugs in Lonsurf, trifluridine and tipiracil, work together to stop cancer cells from growing and might also help kill cancer cells.
How is Lonsurf typically given (administered)? Lonsurf comes in a pill and is taken by mouth.
How are patients typically monitored?
What are the common (occur in 30% or more of patients) side effects of treatment with Lonsurf?
What are the less common (occur in 10% to 29% of patients) side effects of treatment with Lonsurf?
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
Are there any special precautions patients should be aware of before starting treatment?
When should patients notify their physician? Tell your doctor right away if you experience:
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
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