Posted on December 21st, 2015 by
Generic Name: Belimumab
Trade Name: Benlysta®
For which conditions is this drug approved? Benlysta is approved to treat adults with active systemic lupus erythematosus (SLE or lupus) who are receiving other lupus medicines.
What is the mechanism of action? Benlysta belongs to a group of drugs called monoclonal antibodies, which target, bind to, and limit the activity of certain proteins involved in disease processes. In lupus, a protein known as BLyS helps drive the activity of immune cells called B-cells. B-cells paly a role in the inflammatory responses associated with lupus. By limiting the function of BLyS and thereby B-cells, Benlysta helps reduce lupus disease activity.
How is Benlysta typically given (administered)? Benlysta is given through an infusion into a vein (IV infusion). A healthcare provider will administer the infusion, which takes about one hour. Your doctor will decide how often you should receive infusions of Benlysta. Your doctor might also prescribe other medicines for you to take before you receive Benlysta to reduce your risk of a reaction to the infusion.
How are patients typically monitored? During and after the infusion, a healthcare provider will check to make sure you don’t have a bad reaction, including a severe allergic reaction (anaphylaxis). Throughout treatment, your healthcare providers will also monitor you for signs of a serious infection because Benlysta may affect the ability of your immune system to fight infection. You’ll also be asked to contact your doctor if you experience new or worsening depression, suicidal thoughts, or other mood changes.
What are some of the common (occur in 10% to 29% of patients) side effects of treatment with Benlysta?
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
Are there any special precautions patients should be aware of before starting treatment?
When should patients notify their physician?
Tell your doctor right away if you have any of the symptoms listed below while receiving Benlysta:
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
Last updated: 12/15
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