Posted on January 13th, 2016 by
Class: Disease-modifying anti-rheumatic drug (DMARD)
Generic Name: methotrexate
Trade Name: Rasuvo®
For which conditions is this drug approved? Rasuvo is approved to treat adults with severe, active rheumatoid arthritis (RA) and for children with active polyarticular juvenile idiopathic arthritis (pJIA). Rasuvo is approved for use after other medicines, including non-steroidal anti-inflammatory drugs, have been used and did not work well. Rasuvo is not be used for the treatment of cancer.
What is the mechanism of action? Rasuvo inhibits the activity in the body of a folic acid called dihydrofolic acid reductase. In doing so, it is thought that Rasuvo helps control tissue damage in RA by affecting immune function.
How is Rasuvo typically given (administered)? You’ll take Rasuvo as injection with a single-dose, prefilled auto-injector.
How are patients typically monitored? During treatment with Rasuvo, your doctor will check your blood counts and the function of your gastrointestinal system, immune system, liver, nervous system, lungs, and kidneys as well the health your skin.
What are some of the side effects (occur in 10% to 29% of patients) of treatment with Rasuvo?
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
Are there any special precautions patients should be aware of before starting treatment?
When should patients notify their physician?
Call your doctor right away if you have the following symptoms of problems with your organs:
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
Last updated on 09/16.
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