Posted on January 14th, 2016 by
Class: Biological Therapy
Generic Name: alectinib
Trade Name: Alecensa®
For which conditions is this drug approved? Alecensa is approved to treat patients with non-small cell lung cancer (NSCLC) that has a mutation in the anaplastic lymphoma kinase (ALK) gene and has spread to other parts of the body. Alecensa is also approved for patients who have taken the medicine Xalkori® (crizotinib), but their NSCLC has gotten worse or they cannot tolerate Xalkori.
What is the mechanism of action? Alecensa is thought to work by blocking the activity of the ALK protein. Blocking the ALK protein may prevent NSCLC cells from growing and spreading.
How is Alecensa typically given (administered)? You will take Alecensa orally (by mouth) two times a day. Take Alecensa with food and swallow the capsules whole. Do not open or dissolve the capsules.
How are patients typically monitored? During treatment with Alecensa, your doctor will monitor you for the following:
What are the common (occur in 30% or more of patients) side effects of treatment with Alecensa?
What are the less common (occur in 10% to 29% of patients) side effects of treatment with Alecensa?
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
Are there any special precautions patients should be aware of before starting treatment?
When should patients notify their physician?
Tell your healthcare provider right away if you get signs and symptoms of the following:
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
Copyright © 2016 CancerConnect. Last updated 08/16.
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