Posted on January 19th, 2016 by
Class: Biological Therapy
Generic Name: Elotuzumab
Trade Name: Empliciti®
For which conditions is this drug approved? Empliciti is approved to treat patients with multiple myeloma who have received one to three prior treatments. Empliciti is given in combination with the medicines Revlimid® (lenalidomide) and dexamethasone.
What is the mechanism of action? Empliciti belongs to a class of drugs known as monoclonal antibodies. It binds to a protein known as SLAMF7, which is commonly found on the surface of myeloma cells. In doing so, Empliciti activates the body’s immune system to attack and kill multiple myeloma cells.
How is Empliciti typically given (administered)? You’ll receive Empliciti as an intravenous (into the vein) infusion along with Revlimid and dexamethasone. You’ll also receive premedication (before the infusion) with dexamethasone, diphenhydramine, ranitidine, and acetaminophen to lower your risk of infusion reactions. Empliciti is given in 28-day cycles. Your doctor will decide how many cycles you should receive.
How are patients typically monitored?
During treatment with Empliciti, your doctor will check you for the following:
What are the common (occur in 30% or more of patients) side effects of treatment with Empliciti?
What are the less common (occur in 10% to 29% of patients) side effects of treatment with Empliciti?
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
Are there any special precautions patients should be aware of before starting treatment?
When should patients notify their physician?
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
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