Posted on May 10th, 2016 by
Generic Name: Eribulin
Trade Name: Halaven®
For which conditions is this drug approved? Halaven is approved for metastatic breast cancer patients who have had at least two chemotherapy regimens for metastatic disease, including an anthracycline and a taxane. It is also indicated for patients with unresectable or metastatic liposarcoma who have received a prior regimen that includes an anthracycline.
What is the mechanism of action? Halaven is a chemotherapy drug classified as a non-taxane microtubule inhibitor. Microtubules are components of cells that provide structural framework that enables cells to divide and grow. Halaven produces its anti-cancer effects by causing abnormalities in the microtubule formations of the cells which inhibits the cells to replicate, thus ultimately resulting in cell death.
How is Halaven typically given (administered)? Halaven is given as in infusion into a vein.
What are the most common side effects of treatment with Halaven?
What are some of the less common side effects of Halaven?
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What should patients be aware of after treatment with Halaven? Patients should contact their healthcare provider immediately if experiencing a fever of 100.4◦ F (38◦ C) or higher or having chills. This could be a possible sign of infection.
Are there any special precautions patients should be aware of before starting treatment?
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
Important Limitations of Use
The information provided above on the drug you have selected is provided for your information only and is not a substitute for consultation with an appropriate medical doctor. We are providing this information solely as a courtesy and, as such, it is in no way a recommendation as to the safety, efficacy or appropriateness of any particular drug, regimen, dosing schedule for any particular cancer, condition, or patient nor is it in any way to be considered medical advice. Patients should discuss the appropriateness of a particular drug or chemotherapy regimen with their physician.
As with any printed reference, the use of particular drugs, regimens and drug dosages may become out-of-date over time, since new information may have been published and become generally accepted after the latest update to this printed information. Please keep in mind that health care professionals are fully responsible for practicing within current standards, avoiding use of outdated regimens, employing good clinical judgment in selecting drugs and/or regimens, in calculating doses for individual patients, and verifying all dosage calculations.
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