Posted on May 12th, 2016 by
Class: Supportive Care
Generic Name: Defibrotide sodium
Trade Name: Defitelio®
For which conditions is this drug approved? Defitelio is used to treat severe hepatic veno-occlusive disease (VOD) in patients undergoing hematopoietic stem-cell transplantation (HSCT.) Hepatic VOD is a rare, but life-threatening complication that can occur following chemotherapy and a stem cell transplant as treatment for cancer. Hepatic VOD occurs when some of the veins in the liver become blocked, causing swelling and a decrease in blood flow inside the liver.
What is the mechanism of action? The medicines used before a patient undergoes HSCT can damage the lining in the blood vessels in the liver, leading to clots and obstructions of the veins in the liver. Defitelio is a medicine containing the active substance defibrotide which works by increasing the breakdown of clots in the blood.
How is Defitelio typically given (administered)? Defitelio is administered by intravenous infusion.
What are the most common side effects of treatment with Defitelio?
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What are the more serious side effects or precautions of Defitelio?
What should patients be aware of before or during treatment of Defitelio?
Last updated on 05/16.
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