Posted on June 7th, 2016 by
The use of the chemotherapy agent Temodar (temozolomide) following radiation therapy significantly improves time to cancer progression and overall survival among patients with newly diagnosed anaplastic glioma without 1p/19q co-deletions. These results were recently presented at the 2016 annual meeting of the American Society of Clinical Oncology (ASCO).
Anaplastic gliomas are a type of brain cancer that start in a glial cell. Anaplastic gliomas are not common, accounting for only 2% of brain cancers. However, they can be very aggressive and often occur in young adults. Grade III anaplastic glioma refers to an aggressive glioma that can progress into glioblastoma (the most aggressive type of brain cancer) within a few years of its diagnosis.
A recent trial, referred to as the CATNON trial, evaluated the effectiveness of different timing in the delivery of temozolomide in relation to radiation therapy in patients with anaplastic glioma. The trial included approximately 750 patients with newly diagnosed, grade III anaplastic glioma without 1p/19q co-deletions. Patients in the trial were treated with one of the following treatment regimens:
An interim planned analysis reported the following outcomes:
These results indicate that temozolomide delivered after completion of radiation therapy, whether or not it is given concurrently with radiation therapy, significantly improves the time to cancer progression, as well as survival among patients with newly diagnosed, grade III anaplastic glioma without 1p/19q co-deletions.
Longer follow-up and genetic analyses will further elucidate the role of adjuvant temozolomide among this patient population.
Reference: Van Den Bent M, Erridge S, Vogelbaum M, et al. Results of the interim analysis of the EORTC randomized phase III CATNON trial on concurrent and adjuvant temozolomide in anaplastic glioma without 1p/19q co-deletion: An Intergroup trial. Proceedings from the 2016 annual meeting of ASCO. LBA2000. Available at: http://abstracts.asco.org/176/AbstView_176_162108.html. Accessed June 7, 2016.
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