Items Tagged ‘Recurrent Ovarian Cancer’

November 9th, 2016

Lynparza™ Clinical Trial Demonstrates Survival Benefit in Relapsed Ovarian Cancer

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AstraZeneca has announced positive results from the Phase III SOLO-2 trial designed to determine the efficacy of LynparzaTM (olaparib) oral therapy for the maintenance treatment of platinum-sensitive relapsed, BRCA-mutated ovarian cancer.1 Results from the trial demonstrate a clinically-meaningful improvement in survival free of cancer progression. Importantly, the median time to cancer progression for Lynparza-treated patients […]

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Tags: AstraZeneca, BRACAnalysis CDx, brca, lynparza, News, olaprarib, Ovarian Cancer, PARP enzyme, Recurrent Ovarian Cancer, Stage II-IV Ovarian Cancer


October 31st, 2016

Update on PARP Inhibitors for Ovarian Cancer with BRCA Mutations

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Each year in the United States, roughly 22,000 women are diagnosed with ovarian cancer and more than 15,000 die of the disease. Treatment for ovarian cancer commonly involves surgery and/or chemotherapy. Researchers continue to study new approaches for improving the outcomes of all women affected by ovarian cancer but progress has been slow. The PARP […]

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Tags: BRCA1, BRCA2, lynparza, News, niraparib, olaparib, Ovarian Cancer, PARP inhibitor, Recurrent Ovarian Cancer, Rucaparib, Stage I Ovarian Cancer, Stage II-IV Ovarian Cancer


October 20th, 2016

Tesaro Provides Real Benefit to Ovarian Cancer Patients

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Patients with platinum-sensitive recurrent ovarian cancer showed significantly improved cancer-free survival with Tesaro (niraparib) in the first clinical trial directly comparing a poly(ADP)-ribose polymerase (PARP) inhibitor with chemotherapy. Tesaro improved cancer-free survival by 73% in patients with a BRCA mutation and by 55% in those without such mutations. The new data were presented at the […]

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Tags: 2016, BRCA mutation, ESMO, News, niraparib, Ovarian Cancer, parp, poly(ADP)-ribose polymerase, recurrent, Recurrent Ovarian Cancer, Stage II-IV Ovarian Cancer, Tesaro


July 13th, 2016

Niraparib Improves Progression-Free Survival in Ovarian Cancer

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The PARP inhibitor niraparib improves the time to cancer progression among patients with recurrent ovarian cancer when used as maintenance therapy during platinum-based chemotherapy. Each year in the United States, approximately 22,000 women are diagnosed with ovarian cancer, and is the fifth most common cause of cancer-related deaths among women. Since there are no generalized […]

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Tags: BRCA1, BRCA2, News, niraparib, NOVA trial, Ovarian Cancer, PARP inhibitor, Recurrent Ovarian Cancer


June 15th, 2015

Drug Rucaparib Promising in Pretreated BRCA-Positive Ovarian Cancer

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The drug rucaparib appears active in women with recurrent BRCA-positive ovarian cancer that has progressed after previous treatment. These findings were presented at 2015 Annual Meeting of the American Society of Clinical Oncology (May 29–June 2, Chicago, Illinois) and published in the Journal of Clinical Oncology. Each year in the United States, roughly 22,000 women […]

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Tags: BCRA-positive ovarian cancer, News, Ovarian Cancer, PARP inhibitor, Recurrent Ovarian Cancer, Rucaparib


December 29th, 2014

Lynparza Approved in Advanced Ovarian Cancer

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CancerConnect News: The U.S. Food and Drug Administration has granted accelerated approval to LynparzaTM (olaparib), a new drug treatment for women with advanced ovarian cancer associated with defective BRCA genes. According to statistics from the American Cancer Society (ACS), ovarian cancer causes more deaths than any other cancer of the female reproductive system. The ACS […]

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Tags: brca, lynparza, News, olaparib, Ovarian Cancer, parp, Recurrent Ovarian Cancer, Stage II-IV Ovarian Cancer


December 2nd, 2014

Avastin Approved by the FDA for Recurrent Ovarian Cancer

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The FDA approval was based on the results of the AURELIA clinical trial, which involved 361 women with ovarian cancer that had recurred less than 6 months after their most recent platinum-based chemotherapy treatment. The   phase III trial compared chemotherapy alone or in combination with Avastin. Each year in the United States, roughly 22,000 women […]

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Tags: avastin, fda, News, Ovarian Cancer, Recurrent Ovarian Cancer


November 11th, 2014

AFCR Scientists Uncovered Potential New Treatment for Ovarian Cancer

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(CancerConnect) A potential new treatment for ovarian cancer – the most lethal cancer of the female reproductive system – has recently been uncovered, thanks to research supported in part by the Asian Fund for Cancer Research (AFCR). AFCR-funded scientist Wei Zhang, Ph.D., Professor at MD Anderson Cancer Center in the U.S. and Adjunct Professor at […]

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Tags: News, Ovarian Cancer, Recurrent Ovarian Cancer, research


October 21st, 2014

Adding Cediranib to Olaparib Markedly Improves Progression-Free Survival but Increases Toxicity in Recurrent Platinum-Sensitive Ovarian Cancer

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The addition of the antiangiogenic agent cediranib to the PARP inhibitor olaparib in women with recurrent platinum-sensitive ovarian cancer improves time to cancer progression and survival. The results of this study were recently reported in The Lancet Oncology. Each year in the United States, roughly 22,000 women are diagnosed with ovarian cancer and more than […]

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Tags: cedirnaib, News, olaparib, Ovarian Cancer, Recurrent Ovarian Cancer, Stage II-IV Ovarian Cancer