Items Tagged ‘Stage III Melanoma’

October 24th, 2016

Yervoy® Improves Overall Survival in Fully Resected Stage III Melanoma Patients

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Results were presented during the 2016 European Society for Medical Oncology Congress demonstrating that Yervoy® (ipilimumab) compared to placebo improves survival in stage III melanoma patients who are at high risk of recurrence following complete surgical resection. In the study, Yervoy compared with placebo significantly improved overall survival (OS) with five-year OS rates at 65.4% […]

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Tags: 2016, advanced melanoma, ESMO, high-risk, ipilimumab, Melanoma, News, overall survival, stage III, Stage III Melanoma, Yervoy


October 11th, 2016

Epacadostat Plus Keytruda® Appears Effective in Melanoma

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The treatment combination consisting of epacadostat plus Keytruda® (pembrolizumab) appears effective in the treatment of advanced melanoma. Melanoma is a type of skin cancer that often starts in the form of a mole. If detected and treatable with surgery, melanoma has a high cure rate. However, once melanoma invades deeper tissues or spreads from its […]

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Tags: advanced, Epacadostat, keytruda, Melanoma, mole, News, Skin Cancer, Stage III Melanoma, Stage IV Melanoma


September 20th, 2016

Cotellic®/Zelboraf® Combo: New Standard of Care for Melanoma

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The treatment combination consisting of Cotellic® (cobimetinib) plus Zelboraf® (vemurafenib) improves overall survival for patients with advanced, BRAF (V600) mutation-positive melanoma. These confirmatory results have led to this treatment combination being considered as a new standard of care for patients with this disease. These results were recently published in the Lancet Oncology. Melanoma is a […]

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Tags: advanced, BRAF V600, cobimetinib, combination, Melanoma, metastatic, News, Stage III Melanoma, Stage IV Melanoma, vemurafenib


December 2nd, 2015

Opdivo Receives Expanded Approval as Single Agent for Initial Therapy in Melanoma

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The United States Food and Drug Administration (FDA) has approved the PD1 inhibitor, Opdivo (nivolumab), as a single agent for initial therapy of advanced melanoma. This is the sixth indication for which Opdivo has been approved in the past 12 months. The indication for this expanded approval specifies that Opdivo can be used for treatment […]

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Tags: advanced, CheckMate -066 trial, Melanoma, metastatic, News, opdivo, Skin Cancer, Stage III Melanoma, Stage IV Melanoma


November 9th, 2015

Yervoy Gets Expanded Approval for Earlier-Stage Melanoma

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The United States Food and Drug Administration (FDA) has expanded the approval indication for Yervoy (ipilimumab) to include treatment of stage III melanoma. Melanoma is the most deadly form of skin cancer, as it is more likely than other forms of skin cancer to spread from its site of origin to other sites in the […]

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Tags: Melanoma, News, Recurrent Melanoma, Stage III Melanoma


June 29th, 2015

Opdivo® Alone or Combined with Yervoy® Effective in Advanced Melanoma

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Opdivo® (nivolumab) used alone or in combination with Yervoy® (ipilimumab) appears to extend progression-free survival in patients with advanced melanoma. These findings were presented at 2015 Annual Meeting of the American Society of Clinical Oncology (May 29–June 2, Chicago, Illinois) and published in the New England Journal of Medicine. Standard treatment for advanced melanoma typically […]

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Tags: advanced melanoma, ipilimumab, Melanoma, News, nivolumab, opdivo, Stage III Melanoma, Stage IV Melanoma, Yervoy


May 1st, 2015

Melanoma Drug T-VEC Receives Recommendation for FDA Approval

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An advisory panel to the U.S. Food and Drug Administration (FDA) has recommended approval of the investigational drug T-VEC (talimogene laherparepvec) for the treatment of metastatic melanoma. Biopharmaceutical company Amgen recently announced plans to move forward with approval process.[1] The recommendation for approval is based on findings from a Phase III clinical trial in which […]

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Tags: fda, Melanoma, News, Recurrent Melanoma, Stage III Melanoma, Stage IV Melanoma, T-VEC


April 20th, 2015

Keytruda® May Be More Effective than Yervoy® in Advanced Melanoma

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Keytruda® (pembrolizumab) appears to outperform Yervoy® (ipilimumab) at initial treatment of patients with advanced melanoma. Pharmaceutical company Merck announced these Phase III clinical trial findings in a press release in March 2015. Melanoma is less common than non-melanoma skin cancer, but tends to be much more aggressive. What makes melanoma so dangerous is that it […]

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Tags: advanced melanoma, ipilimumab, KEYNOTE-006, keytruda, Melanoma, News, pembrolizumab, Stage III Melanoma, Stage IV Melanoma, Yervoy


February 6th, 2015

Yervoy® Improves Treatment of Stage III Melanoma

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CancerConnect News: The first trial of the immunomodulator Yervoy® (ipilimumab) conducted in patients with stage III melanoma appears promising, demonstrating an improvement by delaying cancer recurrence and improving survival. Skin cancer is the most common form of cancer in the United States, with more than one million new cases each year. Skin cancer is often […]

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Tags: ipilimumab, Melanoma, News, stage 3 melanoma, Stage III Melanoma, Yervoy


December 8th, 2014

Yervoy® May be Beneficial in Uveal Melanoma

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The first trial of the immunomodulator Yervoy® (ipilimumab) conducted in patients with uveal melanoma appears promising in according to the results of a small clinical trial presented at the recent Society of Melanoma Research (SMR) 2014 International Congress, in Zurich, Switzerland. Uveal melanoma is the most common cancer of the eye in adults, and the […]

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Tags: ipilimumab, Melanoma, News, Recurrent Melanoma, Stage III Melanoma, Stage IV Melanoma, uveal melanoma, Yervoy


November 25th, 2014

PV-10 Injection is Promising Treatment of Melanoma Lesions

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The results of an international clinical trial evaluating the use of intralesional rose bengal (PV-10), injected in 80 patients with refractory cutaneous or subcutaneous metastatic melanoma were recently reported. PV-10 is a 10% solution of Rose Bengal, which was originally used as an agent to stain necrotic tissue in the cornea. Its potential use in […]

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Tags: intralesional, Melanoma, News, pv-10, Recurrent Melanoma, Stage III Melanoma, Stage IV Melanoma, Stages I-II Melanoma, subcutaneous


November 24th, 2014

New Information Helps Understanding Immunotherapy’s Successes—And Its Failures

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(OMNI- CancerConnect) A collaborative team of leaders in the field of cancer immunology from Memorial Sloan Kettering Cancer Center has made a key discovery that advances the understanding of why some patients respond to ipilimumab, an immunotherapy drug, while others do not.  MSK was at the forefront of the clinical research that brought this CTLA-4 […]

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Tags: immunotherapy, ipilimumab, Melanoma, News, Recurrent Melanoma, Stage III Melanoma, Stage IV Melanoma, Yervoy


November 14th, 2014

Progress in the Treatment of Advanced Melanoma and Other Skin Cancers

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By one estimate, over the past three decades more people in the United States have had skin cancer than all other cancers combined.1 According to the American Cancer Society, 3.5 million cases of basal and squamous cell skin cancer are diagnosed each year.2 Rates of melanoma—the deadliest form of skin cancer—are on the rise,2 particularly […]

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Tags: anti-PD-1, basal cell, General Skin Cancer, keytruda, Melanoma, News, pembrolizumab, Recurrent Melanoma, Skin Cancer, Skin Cancer Overview, Stage III Melanoma, Stage IV Melanoma


October 8th, 2014

COMBI-v BRAF/MEK Inhibitor Combination Trial Impressive in Melanoma

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For advanced melanoma patients with BRAF mutations, two pathway inhibitors are much better than one, according to a study presented at the European Society for Medical Oncology Meeting this week. Of the more than one million new diagnoses of skin cancer each year, roughly 68,000 involve melanoma. More than 8,000 people die of melanoma each […]

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Tags: Melanoma, News, Recurrent Melanoma, Stage III Melanoma, Stage IV Melanoma, tafinalr, trametinib, zelboraf


October 2nd, 2014

BRAF/MEK Inhibitor Combination Impressive in Melanoma Trials

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For advanced melanoma patients with BRAF mutations, two pathway inhibitors are much better than one, according to a study presented at the European Society for Medical Oncology Meeting this week. Of the more than one million new diagnoses of skin cancer each year, roughly 68,000 involve melanoma. More than 8,000 people die of melanoma each […]

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Tags: BRAF, cobimetinib, cobrim, mek, Melanoma, News, Recurrent Melanoma, Stage III Melanoma, Stage IV Melanoma, vemurafenib, zelboraf