Items Tagged ‘Stages IIIB-IV Lung Cancer – Non-Small Cell’

October 27th, 2016

Precision Medicine Guides NSCLC Cancer Treatment: All Patients Should Undergo Molecular Testing

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Lung cancer remains the leading cause of cancer-related deaths worldwide. In the United States, non-small cell lung cancer (NSCLC) accounts for 75–80% of all lung cancers. Although progress has been made in recent years, the majority of patients with advanced stage lung cancer still die from their disease. Precision medicine continues to impact the lives […]

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Tags: General Lung Cancer, immune response, keytruda, Lung Cancer, Lung Cancer - Non-Small Cell, News, nivolumab, nsclc, opdivo, PD-1 inhibitors, pembrolizumab, precision medicine


October 25th, 2016

Keytruda Approved for First-Line Treatment of Select Patients with Advanced Non-Small Cell Lung Cancer

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The US Food and Drug Administration (FDA) has approved Keytruda® (pembrolizumab) as a first-line treatment options for patients with metastatic non-small cell lung cancer (NSCLC) whose tumors express high levels of PD-L1 without EGFR or ALK mutations. PD-1 is a protein that inhibits certain types of immune responses. Drugs that block PD-1, such as Keytruda […]

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Tags: fda, keytruda, Lung Cancer, Lung Cancer - Non-Small Cell, News, non-small cell lung cancer, nsclc, Recurrent Lung Cancer - Non-Small Cell, Stages IIIB-IV Lung Cancer - Non-Small Cell


October 25th, 2016

Tecentriq® Improves NSCLC Survival Compared to Chemotherapy Regardless of PD-L1 Status

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Tecentriq® (atezolizumab) improves the outcomes of individuals with advanced non-small cell lung cancer (NSCLC) according to the results of a pivotal clinical trial presented at the European Society of Medical Oncology (ESMO) 2016 Annual Meeting this week. Tecentriq is an agent that stimulates the immune system to recognize and mount an immune attack against cancer […]

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Tags: 2016, atezolizumab, BTD, ESMO, General Lung Cancer, Lung Cancer, Lung Cancer - Non-Small Cell, monoclonal antibody, News, nsclc, PD-L1, Recurrent Lung Cancer - Non-Small Cell


October 19th, 2016

Immunotherapy May Become New Standard of Care in Advanced Non-Small Cell Lung Cancer

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Researchers presented full results of Keytruda® (pembrolizumab) and Opdivo® (nivolumab) in previously untreated advanced non-small cell lung cancer (NSCLC) at the European Society for Medical Oncology annual meeting in Copenhagen. An additional study was also recently published in the New England Journal of Medicine evaluating Keytruda in previously treated patients with advanced NSCLC . Results of […]

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Tags: 2016, advanced, ESMO, General Lung Cancer, keytruda, Lung Cancer, Lung Cancer - Non-Small Cell, News, nsclc, opdivo, PD-1, pembrolizumab


September 14th, 2016

FDA Grants Breakthrough Therapy Designation to Keytruda® for First-Line Treatment of Patients with Advanced Non-Small Cell Lung Cancer

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The U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation for Keytruda® (pembrolizumab) for first-line treatment of patients with advanced non-small cell lung cancer (NSCLC). The FDA’s Breakthrough Therapy Designation is intended to expedite the development and review of a drug that is planned for use to treat a serious or life-threatening disease […]

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Tags: advanced, General Lung Cancer, KEYNOTE-024, Lung Cancer, Lung Cancer - Non-Small Cell, Merck, News, nsclc, pembrolizumab, Stages IIIB-IV Lung Cancer - Non-Small Cell


September 13th, 2016

Whole-Brain Radiotherapy Fails to Benefit Most Patients with Lung Cancer

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Whole-brain radiotherapy (WBRT) provides “little additional clinically significant benefit” for patients with non–small cell lung cancer (NSCLC) with brain metastases, according to doctors performing the first large-scale randomized controlled trial of its kind. As many as 30% of all patients with NSCLC will present with or develop brain metastases. There is currently a routine practice […]

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Tags: advanced, brain metastases, General Lung Cancer, Lung Cancer, Lung Cancer - Non-Small Cell, News, nsclc, QUARTZ, Recurrent Lung Cancer - Non-Small Cell, Stages IIIB-IV Lung Cancer - Non-Small Cell, surgery, WBRT


November 10th, 2015

Updated Results Confirm Improved Survival with Opdivo® in Lung Cancer

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Longer follow-up confirms the survival benefit with the use of the PD-1 inhibitor, Opdivo® (nivolumab), compared to the chemotherapy agent, docetaxel, among patients with recurrent non-small cell lung cancer (NSCLC). These results were recently published in the New England Journal of Medicine while simultaneously being presented at the 2015 European Cancer Congress. Lung cancer remains […]

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Tags: advanced, docetaxel, Lung Cancer, Lung Cancer - Non-Small Cell, News, nivolumab, non-squamous, nsclc, opdivo, PD-1 inhibitor, Recurrent Lung Cancer - Non-Small Cell, squamous


September 23rd, 2015

Iressa® Approved as Initial Therapy for Lung Cancer

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The targeted agent Iressa (gefitinib) has been approved by the U.S. Food and Drug Administration (FDA) as initial therapy in the treatment of patients with advanced lung cancer. Specifically, Iressa was approved as initial therapy for the treatment of patients with advanced non-small cell lung cancer (NSCLC) with specific mutations within the EGFR pathway. The […]

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Tags: advanced lung cancer, EGFR mutations, EGFR RGQ PCR Kit, FDA approval, gefitinib, iressa, Lung Cancer - Non-Small Cell, News, nsclc, Stages IIIB-IV Lung Cancer - Non-Small Cell


July 20th, 2015

FDA Approves Iressa for Treatment of Patients with Metastatic Non Small Cell Lung Cancer

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The U. S. Food and Drug Administration approved IRESSA (gefitinib) for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations as detected by an FDA-approved test. Gefitinib is being approved concurrently with a labeling expansion of […]

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Tags: FDA approval, gefitinib, Lung Cancer - Non-Small Cell, metastatic non-small cell lung cancer, News, nsclc, Stages IIIB-IV Lung Cancer - Non-Small Cell


June 25th, 2015

Aetna Provides Coverage for Biodesix’ VeriStrat Test

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Biodesix, Inc. announced that its VeriStrat® test is now considered a medically necessary benefit by Aetna Corporation (NYSE: AET).  Aetna published a positive coverage policy for the VeriStrat proteomic test on June 5th, stating the test is medically necessary “for patients with advanced NSCLC, whose tumors were without EGFR and anaplastic lymphoma kinase (ALK) mutations…” Aetna’s […]

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Tags: health coverage, Lung Cancer - Non-Small Cell, News, non-small cell lung cancer, nsclc, proteomic blood test, Stages IIIB-IV Lung Cancer - Non-Small Cell, VeriStrat test


February 26th, 2015

FDA Grants Breakthrough Therapy Designation for MPDL3280A, an anti-PDL1 Investigational Cancer Immunotherapy for Non-Small Cell Lung Cancer

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The investigational cancer immunotherapy MPDL3280A (anti-PDL1) has received Breakthrough Therapy Designation from the U.S. Food and Drug Administration (FDA). The designation was granted for the treatment of people with PD-L1 (Programmed Death-Ligand 1) positive non-small cell lung cancer (NSCLC) whose disease has progressed during or after platinum-based chemotherapy. Lung cancer remains the leading cause of […]

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Tags: anti-PDL1, Breakthrough Therapy Designation, Lung Cancer, Lung Cancer - Non-Small Cell, MPDL3280A, News, non-small cell lung cancer, nsclc, PDL1, Recurrent Lung Cancer - Non-Small Cell, Stages IIIB-IV Lung Cancer - Non-Small Cell


February 11th, 2015

NFCR-Support Research Finds New Way to Combat Resistant Lung Cancer

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A team of researchers at Massachusetts General Hospital has developed a new platform that can rapidly identify effective drug combinations for lung cancer patients whose tumors have stopped responding to targeted therapy. The research, which was supported in part by the National Foundation for Cancer Research (NFCR), is a critical milestone on the road to […]

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Tags: Extensive Lung Cancer - Small Cell, General Lung Cancer, Lung Cancer, Lung Cancer - Non-Small Cell, Lung Cancer - Small Cell, lung cancer research, News, Recurrent Lung Cancer - Non-Small Cell, refractory, resistant, Stages IIIB-IV Lung Cancer - Non-Small Cell


February 10th, 2015

Addition of Linifanib to Carboplatin-Paclitaxel Increases Progression-Free Survival and Toxicity in Advanced Nonsquamous NSCLC

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In a phase II trial reported in the Journal of Clinical Oncology doctors reported that the addition of linifanib to carboplatin-paclitaxel chemotherapy the outcomes in patients with advanced nonsquamous non–small cell lung cancer (NSCLC). However the addition of linifanib did result in greater side effects from treatment. Lung cancer remains the leading cause of cancer-related […]

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Tags: General Lung Cancer, linifanib, Lung Cancer, Lung Cancer - Non-Small Cell, News, non-small cell lung cancer, nonsquamous, nsclc, Recurrent Lung Cancer - Non-Small Cell, Stages IIIB-IV Lung Cancer - Non-Small Cell


January 21st, 2015

Stereotactic Body Radiation Therapy Improves Survival in Stage IV Non Small Cell Lung Cancer and Represents New Treatment Option

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The results of a recent clinical trial published in the Journal of Clinical Oncology in patients with stage IV non small cell lung caner (NSCLC) suggest that combining stereotactic body radiation therapy (SBRT) with Tarceva (erlotinib) chemotherapy significantly improve survival. Lung cancer remains the leading cause of cancer death in the United States and abroad, […]

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Tags: erlotinib, General Lung Cancer, Lung Cancer, Lung Cancer - Non-Small Cell, News, non-small cell lung cancer, nsclc, radiation, Recurrent Lung Cancer - Non-Small Cell, sbrt, Stages IIIB-IV Lung Cancer - Non-Small Cell, stereotactic body radiation


December 9th, 2014

Dacomitinib Shows Activity in Selected Patients With Advanced Non-Small Cell Lung Cancer

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In a phase II trial reported in The Lancet Oncology, doctors from Dana Farber Cancer Institute in Boston found that treatment of patients with advanced non–small cell lung cancer (NSCLC) with EGFR mutations or clinical characteristics associated with response to EGFR inhibitors with the targeted pan-HER inhibitor dacomitinib was promising. A targeted therapy is one […]

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Tags: dacomitinib, Lung Cancer, Lung Cancer - Non-Small Cell, News, non-small cell lung cancer, nsclc, Recurrent Lung Cancer - Non-Small Cell, Stages IIIB-IV Lung Cancer - Non-Small Cell