Andrey Dobroff, PhD
Research Assistant Professor
Department of Internal Medicine
Division of Molecular Medicine
Cellular and Molecular Oncology
My research interests involve the development of a broad understanding of the molecular events regulating tumor progression and metastasis and the identification of new targets for drug development and therapy. My academic training and research experience have provided me with an excellent background in multiple disciplines including molecular biology, immunology, biochemistry, and cell biology. I have extensive experience with state-of-the-art methods including lentiviral, siRNA and shRNA, gene expression profiling and gene microarray, phage display as well as the development of monoclonal antibodies. In my laboratory, we are currently working to elucidate how the lymphatic and the melanoma cells interact with each other and how this interaction facilitates metastasis. Such project is based on previously published findings (PNAS, 2015) where a new lymphatic-specific cell surface marker - the Protein Phosphatase 2, Regulatory Subunit A, Alpha (PPP2R1A)
- was found to be directly correlated with the melanoma stage and the degree of lymph node (LN) involvement. A thorough and systematic study is being carried out to characterize the function of PPP2R1A in melanoma. These efforts may redefine a fundamental paradigm in lymphatic metastasis and enhance our understanding of the molecular mechanisms underlying the metastatic process through the lymphatic system.