Cédric Cleyrat, PhD
Research Assistant Professor,
Department of Pathology
Translational Cancer Biology and Signaling
University of Nantes/INSERM, France
University of New Mexico (Cell Pathology/Hematology)
My research interests are focused on understanding how protein interactions and trafficking events, within the overall cell architecture, are related to pathogenic mechanisms in cancer. During the past few years, I have been able to build on my solid background in molecular and cellular biology by acquiring skills in state-of-the-art biochemical and imaging techniques. One of my two main scientific foci is on the high affinity receptor for IgE, the FcÎµRI, and its implication in allergies, asthma and mast cell diseases. I am applying my unique skill set to the dissection of FcÎµRI signal initiation and the spatiotemporal coordination of endocytic trafficking by signaling and adaptor proteins. My second area of research aims at uncovering the underlying mechanisms of the myeloproliferative neoplasms (MPNs) pathogenesis. I am characterizing the complex interplay between Jak2, Mpl and calreticulin, the three main players in MPNs, and their altered trafficking-related signaling properties. My long term goals are to bring new perspectives to my fields of study, using my expertise to develop innovative investigation methods, and to lead basic science projects toward translational applications.