Cédric Cleyrat, PhD

Cédric Cleyrat, PhD

Faculty Titles
Research Assistant Professor,
Department of Pathology

Research Program
Translational Cancer Biology and Signaling

NIH Biosketch
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Graduate School
University of Nantes/INSERM, France

Research Fellowship
University of New Mexico (Cell Pathology/Hematology)

Personal Statement
My research interests are focused on understanding how protein interactions and trafficking events, within the overall cell architecture, are related to pathogenic mechanisms in cancer. During the past few years, I have been able to build on my solid background in molecular and cellular biology by acquiring skills in state-of-the-art biochemical and imaging techniques. One of my two main scientific foci is on the high affinity receptor for IgE, the FcεRI, and its implication in allergies, asthma and mast cell diseases. I am applying my unique skill set to the dissection of FcεRI signal initiation and the spatiotemporal coordination of endocytic trafficking by signaling and adaptor proteins. My second area of research aims at uncovering the underlying mechanisms of the myeloproliferative neoplasms (MPNs) pathogenesis. I am characterizing the complex interplay between Jak2, Mpl and calreticulin, the three main players in MPNs, and their altered trafficking-related signaling properties. My long term goals are to bring new perspectives to my fields of study, using my expertise to develop innovative investigation methods, and to lead basic science projects toward translational applications.