Diane Lidke, PhD
Department of Pathology
Cellular and Molecular Oncology
My research integrates the disciplines of biophysics, bio-imaging and quantitative biology to gain new and fundamental understanding of the components and dynamics of cell signaling pathways. This involves the measurement of protein behavior in living cells to capture and quantify biochemical events that initiate signaling. My lab focuses on the study of the IgE Receptor and the EGFR/erbB family of receptor tyrosine kinases, and how these are altered in diseased cells or influenced by therapeutics. I have a strong track-record of developing innovative ways to measure biological processes and was a recipient of the 2011 Biophysical Society’s Margaret Oakley Dayhoff Award for my “innovative work integrating the disciplines of biophysics, bioimaging and quantitative biology.” My expertise in live cell imaging includes techniques such as FRAP, FCS, FRET, hyperspectral imaging, super-resolution microscopy and single particle tracking as well as development of techniques for live cell labeling of proteins of interest with fluorescent proteins and/or quantum dot probes [1-4]. I am a director of the UNM Fluorescence Microscopy Shared Resource and co-director of the NM Spatiotemporal Modeling Center, an NIH-funded systems biology center.