Ellen Beswick, PhD
Department of Molecular Genetics & Microbiology
Translational Cancer Biology and Signaling
The goal of my research program is to examine several novel inflammatory pathways in gastrointestinal cancers that link inflammation and tumor development and progression. The long term goal of this work is to lead to development of new therapeutics to target these diseases. I examine the interplay between the GI tumor microenvironment and immune cells, which leads to tumor growth. As a New Investigator, I am qualified to participate in this project for the following reasons: 1) I was awarded a K22 career development award and an ACS Research Scholar Grant with which I have set up an independent laboratory, and managed budgets and personnel. 2) My previous training focused on chronic inflammation, Inflammatory Bowel Diseases, T cell immunology, and Gastrointestinal cancers. 3) I have developed methods to process human and mouse tissues for primary culture and to analyze proinflammatory immune cell phenotype development and their role in pro-carcinogenic mechanisms. 4) I have developed collaborations with the Chief of Gastroenterology, Surgical Oncologists, and Pathologists to develop new translational approaches in gastrointestinal pathobiology. 5) As a faculty member in the Department of Molecular Genetics and Microbiology and the Clinical and Translational Sciences Center, I have an established support system including mentors, collaborators, and access to the resources of both. My long term goal is to be an expert in gastrointestinal inflammatory diseases, T cell immunology, and the links between chronic inflammation and carcinogenesis. I have a successful track record of productive research, funding, resources, and institutional support to successfully complete the proposed studies.