Judy Cannon, PhD
Department of Molecular Genetics & Microbiology
Cellular and Molecular Oncology
The goal of my laboratory is to study the signals that drive migration and tissue specific residency of both normal and leukemic T cells using cutting edge two photon microscopy combined with computational analysis and modeling. My training in immunology focused on the understanding of how signaling networks function together to control T cell activation and migration. My predoctoral training in the laboratory of Dr. Janis Burkhardt used fluorescence microscopy and mutational analysis to identify the domains within the Wiskott-Aldrich Syndrome Protein that regulated its localization to the immunological synapse. I then joined the laboratory of Dr. Anne Sperling to study the role of the molecule CD43 in regulating T cell function. In Dr. Sperling’s lab, I helped to identify a novel function for CD43 in regulating T cell migration. Since establishing my own laboratory at the University of New Mexico School of Medicine, I have focused my work on developing novel methods of imaging T cell motion in intact tissues and also computationally modeling normal and leukemic T cell migration. We recently published studies showing specialized motion of T cells in the lung using a combination of two photon imaging of intact lung and computational analysis (a). In addition, I showed a novel role for CARMA1 in regulating leukemia cell accumulation in the CNS of animals with T- ALL (b). I routinely use flow cytometry, two photon imaging, and bioluminescent imaging, quantitatively analysis, and computational modeling to understand migration patterns of both leukemic T cells and how key signaling pathways can change our understanding of leukemia cell migration through tissues such as the CNS. At the University of New Mexico, I am member of the University of New Mexico Health Sciences Center Cancer Center which is a Comprehensive NCI designated Cancer Center as well as co-investigator of the NIGMS funded Spatiotemporal Modeling Systems Biology Center. I am also a Core director for the Autophagy, Inflammation, and Metabolism Center of Biomedical Research Excellence Inflammation and Metabolism Core.