Scott Burchiel, PhD

Scott Burchiel, PhD

Faculty Titles
Professor,
College of Pharmacy

Research Program
Cellular and Molecular Oncology

Personal Statement

I have been an NIH-funded PI for greater than 30 years. We have performed immune function studies using human peripheral blood mononuclear cells (HPBMC) from study populations in Bangladesh and have found that arsenic is suppressive to immune function. Arsenic suppresses DNA repair and appears to act synergistically with polycyclic aromatic hydrocarbons (PAHs) to produce DNA damage. Suppressed immune function is expected to result in increased upper airway infections and upper airway cancers. Therefore, it is very important to assess individual immune status in upper airways, as well as to assess the viruses and bacterial (pathogenic and healthy) metagenomes that may play important roles in pulmonary health and disease. We have established collaborations with leading microbiome scientists, immunologists, toxicologists, and environmental public health scientists that will allow us to develop and validate novel technologies. A healthy immune system plays a paramount role in the control of cancer in humans