Scott Ness, PhD

Scott Ness, PhD

Faculty Titles
Department of Internal Medicine
Division of Molecular Medicine

UNM Cancer Center Position(s)
Associate Director for Shared Resources
Director, Analytical and Translational Genomics Shared Resource

The Victor and Ruby Hansen Surface Endowed Professor in Cancer Genomics

Research Program
Cellular and Molecular Oncology

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Graduate School
PhD, University of California, Los Angeles, 1985

Research Fellowship
European Molecular Biology Laboratory, Heidelberg, 1992

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Personal Statement

The research in my laboratory extends from basic science to translational research to technology development. The c-Myb transcription factor is a key and essential regulator of hematopoiesis and plays important roles in epithelial and some neural cells. We have developed novel and innovative approaches for following changes in c-Myb during the cell cycle and are mapping domains in the protein responsible for cell cycle-dependent changes in transcriptional activities. The c-Myb protein is a critical regulator of cell fate, controlling whether cells continue proliferating or differentiate. We found that the c-myb gene encodes at least 60 different splice variants, and that the expression of specific variants correlates with poor prognosis and poor survival in leukemia patients. This provides a novel type of biomarker for analyzing and classifying leukemia patients, and we have developed high-throughput methods using next-generation sequencing technologies to take advantage of this approach.