The Fan lab in the Cancer Genetics, Epigenetics, and Genomics Research Program at the University of New Mexico Comprehensive Cancer Center (UNMCCC) is seeking for one highly motivated postdoctoral researcher to investigate the epigenetic mechanisms of mitotic transcriptional memory. Currently, we aim to unravel the pathogenesis mechanisms of T-cell acute lymphoblastic leukemia (T-ALL) through the Notch signaling effector RBPJ. T-ALL is an aggressive cancer that preferentially affects children and adolescents, with more than 50% of T-ALL cases having aberrant Notch signal activation. RBPJ is a sequence-specific transcription factor that associates with activated Notch and mediates the vast majority of Notch signals arising from all four receptors. Current projects focus on the understanding of how RBPJ interacts with mitotic chromatin to regulate gene expression as well as maintain cell fate and that should reveal novel regulatory points for manipulating aberrant Notch signaling for cancer therapeutics.
UNMCCC provides a highly interactive and supportive environment for junior investigators to grow and develop their future career. Publications from the Fan lab on National Center for Biotechnology Information (NCBI), on the Fan Laboratory webpage, and on Vivo.
Qualifications: Ph.D. in Biochemistry, Molecular Biology, Cell Biology or Genetics. Individuals with a strong background in epigenetics or aspects of chromatin biology are encouraged to apply. Prior experiences in chromatin IP, protein complex purification or stem cell biology are highly desirable. To apply, send a CV, including a list of three references to Hua-Ying Fan, Ph.D. (firstname.lastname@example.org) using “application for a postdoctoral researcher position” on the subject line.