The primary focus of my research program is to understand the genetic basis of ovarian cancer and to define and characterize the functional contribution of cancer genes in molecular carcinogenesis, tumor progression, and treatment response.
During my postdoctoral training, I characterized the function of three novel candidate tumor supressor genes (TSGs), namely HTRA1, SULF1, and TCEAL7. These studies focused on:
- Genetic mechanisms to explain the loss of expression of these candidate TSGs in ovarian cancer
- How these genes regulate cell proliferation, growth factor signaling, and apoptosis
- How these genes modulate sensitivity to chemotherapy
As an independent investigator, my current research program in Applied Genomics and Cancer Therapeutics (AGCT) focuses on cracking the genetic code of ovarian cancer. Three areas of my research focus on Cancer Genomics, Functional Genomics, and Precision Therapeutics.
Towards the goal of raising the standard of care for patients with ovarian cancer, we are:
- Developing bioinformatic tools to gain novel insights into the genetics of ovarian cancer from next-generation sequencing data
- Performing functional genomic screens to identify genetic vulnerabilities in cancer
- Developing strategies to target critical cancer genes and pathways for precision therapeutics