outdated_browser_message

Chien Laboratory

Jeremy Chien, PhD

Endowed Professor in Cancer Genomics and Target Discovery

Jeremy Chien

The primary focus of my research program in Applied Genomics and Cancer Therapeutics (AGCT) is to understand the genetic basis of ovarian cancer and to develop novel therapies that exploit genetic deficiencies in ovarian cancer.

We are also developing novel experimental therapeutics that target genetic and functional dependencies in ovarian cancer to achieve effective and durable treatments for ovarian cancer. In particular, I have the following programs:

  1. Cancer Genomics: Funded by the Department of Defense Ovarian Cancer Academy and the American Cancer Society Research Scholar grant, this research program focuses on understanding the biological pathways contributing to chemotherapy resistance.
  2. Tumor microenvironment in ovarian cancer progression and metastasis: This program focuses on dissecting the role of serine protease HtrA1 in TGF-β signaling, epithelial-mesenchymal transition, cell-cell and cell-matrix adhesion, immune modulation and metastasis.
  3. Functional Genomics and Target Discovery: Funded by the Department of Defense Ovarian Cancer Research Program and the American Cancer Society Research Scholar grant, this program focuses on applying forward genetic screens to identify genetic dependencies and vulnerabilities in ovarian cancer and developing novel therapeutics targeting synthetic lethal interactions in ovarian cancer.

Mission Statement

The primary focus of my research program is to understand the genetic basis of ovarian cancer and to define and characterize the functional contribution of cancer genes in molecular carcinogenesis, tumor progression, and treatment response.

During my postdoctoral training, I characterized the function of three novel candidate tumor supressor genes (TSGs), namely HTRA1, SULF1, and TCEAL7. These studies focused on:

  1. Genetic mechanisms to explain the loss of expression of these candidate TSGs in ovarian cancer
  2. How these genes regulate cell proliferation, growth factor signaling, and apoptosis
  3. How these genes modulate sensitivity to chemotherapy

As an independent investigator, my current research program in Applied Genomics and Cancer Therapeutics (AGCT) focuses on cracking the genetic code of ovarian cancer. Three areas of my research focus on Cancer Genomics, Functional Genomics, and Precision Therapeutics.

Towards the goal of raising the standard of care for patients with ovarian cancer, we are:

  1. Developing bioinformatic tools to gain novel insights into the genetics of ovarian cancer from next-generation sequencing data
  2. Performing functional genomic screens to identify genetic vulnerabilities in cancer
  3. Developing strategies to target critical cancer genes and pathways for precision therapeutics

Using integrated approaches in genomics, functional genomics, and molecular genetics, the Chien Lab is characterizing the functional consequences of genetic and genomic alterations in ovarian cancer and their roles in recurrent disease and chemotherapy resistance.

Questions? Contact Us

Name (required)

Email (required)

Subject

Message

Summary

    • NIH Biosketch
    • Publications (complete list)

Roles at the Mayo Clinic, Rochester:
• Associate Consultant, 2008-2012
• Assistant Professor, 2006-2012
• Research Associate, 2004-2006

PhD from The University of Kansas Medical Center, 2000

##wp_footer|force_flag=1##