Chien Lab

Jeremy Chien

Jeremy Chien, PhD

Endowed Professor in Cancer Genomics and Target Discovery
PhD, The University of Kansas Medical Center, 2000
Postdoctoral, Mayo Clinic, 2000-2006

Research Focus

The primary focus of my research program in Applied Genomics and Cancer Therapeutics (AGCT) is to understand the genetic basis of ovarian cancer and to develop novel therapies that exploit genetic deficiencies in ovarian cancer. Using integrated approaches in genomics, functional genomics, and molecular genetics, I am characterizing the functional consequences of genetic and genomic alterations in ovarian cancer and their roles in recurrent disease and chemotherapy resistance. We are also developing novel experimental therapeutics that target genetic and functional dependencies in ovarian cancer to achieve effective and durable treatments for ovarian cancer. In particular, I have the following programs:

  1. Cancer Genomics: Funded by the Department of Defense Ovarian Cancer Academy and the American Cancer Society Research Scholar grant, this research program focuses on understanding the biological pathways contributing to chemotherapy resistance.
  2. Tumor microenvironment in ovarian cancer progression and metastasis: This program focuses on dissecting the role of serine protease HtrA1 in TGF-β signaling, epithelial-mesenchymal transition, cell-cell and cell-matrix adhesion, immune modulation and metastasis.
  3. Functional Genomics and Target Discovery: Funded by the Department of Defense Ovarian Cancer Research Program and the American Cancer Society Research Scholar grant, this program focuses on applying forward genetic screens to identify genetic dependencies and vulnerabilities in ovarian cancer and developing novel therapeutics targeting synthetic lethal interactions in ovarian cancer.

Selected Publications

The Cancer Genome Atlas Research Network, (Participants are arranged by area of contribution and then by institution.), Disease working group and tissue source sites, Bell D, Berchuck A, Birrer M, Chien J, Cramer DW, Dao F, Dhir R, Disaia P, Gabra H, Glenn P, Godwin AK, Gross J, Hartmann L, Huang M, Huntsman DG, Iacocca M, Imielinski M, Kalloger S, Karlan BY, Levine DA, Mills GB, Morrison C, Mutch D, Olvera N, Orsulic S, Park K, Petrelli N, Rabeno B, Rader JS, Sikic BI, Smith-McCune K, Sood AK, (2011)Integrated genomic analyses of ovarian carcinoma. Nature 474:609-15.

Mullany SA, Moslemi-Kebria M, Rattan R, Khurana A, Clayton A, Ota T, Mariani A, Podratz KC, Chien J*, Shridhar V*. (2011)Expression and functional significance of HtrA1 loss in endometrial cancer. Clin Cancer Res. 17:427-36. *Co-corresponding authors

Ota T, Clayton AC, Minot DM, Shridhar V, Hartmann LC, Gilks CB, Chien J. (2011) Minichromosome Maintenance Protein 7 as a Potential Prognostic Factor for Progression-Free Survival in High-Grade Serous Carcinomas of the Ovary. Mod Pathol 24:277-87.

Chien J, Takayo Ota, Giovanni Aletti, Ravi Shridhar, Mariarosaria Boccellino, Lucio Quagliuolo, Alfonso Baldi, and Viji Shridhar. (2009) Serine protease HtrA1 associates with microtubules and inhibits cell migration. Molecular and Cellular Biology 29:4177-87.

Chien J, Jian-Bing Fan, Debra A. Bell, Craig April, Brandy Klotzle, Takayo Ota, Wilma L. Lingle, Jesus Gonzalez Bosquet, Viji Shridhar, and Lynn C. Hartmann. (2009) Analysis of Gene Expression in Stage I Serous Epithelial Ovarian Cancer Identifies Critical Pathways Altered in Ovarian Cancer. Gynecologic Oncology 114:3-11.

Chien J, Xiaoping He, and Viji Shridhar*. (2009) Identification Of Tubulins As Substrates Of Serine Protease HtrA1 By Mixture-Based Oriented Peptide Library Screening. Journal of Cellular Biochemistry 107:253-63

Funmi Ajayi, Nickalus Congosoa, Thomas Gaffey, William Watson, Alfonso Baldi, Peeyush Lala, Viji Shridhar, Brian Brost, and Chien J. (2008) Elevated expression of HtrA1 in preeclampsia and its role in trophoblast cell migration and invasion. Am J Obstetrics & Gynecology 199:557.e1-10.

Chien J, Keishi Narita, Ramandeep Rattan, Shailendra Giri, Ravi Shridhar, Julie Staub, Daniah Beleford, Jinping Lai, Julian Molina, Scott H. Kaufmann, George C. Prendergast, and Viji Shridhar. (2008) Candidate tumor suppressor gene TCEAL7 negatively regulates c-Myc. Oncogene 27:7223-34.

Chien J, Aletti G, Baldi A, Catalano V, Muretto P, Keeney GL, Kalli KR, Staub J, Ehrmann M, Cliby WA, Lee YK, Bible KC, Hartmann LC, Kaufmann SH, Shridhar V. (2006) Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity. J Clin Invest. 116:1994-2004.

Chien J, Staub J, Avula R, Zhang H, Liu W, Hartmann LC, Smith DI, and Shridhar V. (2005) Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer. Oncogene 24:5089-100.

Chien J, Staub J, Hu SI, Erickson-Johnson MR, Couch FJ, Smith DI, Crowl RM, Kaufmann SH, Shridhar V. (2004) A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer. Oncogene 23:1636-44.

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