Items Tagged ‘afinitor’

June 19th, 2017

FDA Fast Track Designation Granted To CB-839 For Treatment Of Patients With Renal Cell Carcinoma

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The U.S. Food and Drug Administration (FDA) has granted Fast Track designation to CB-839 in combination with afinitor® (everolimus), for the treatment of patients with metastatic renal cell carcinoma who have received 2 or more prior lines of therapy.  CB-839 is a first-in-class, oral, selective, potent inhibitor of glutaminase being evaluated in Phase 1/2 clinical […]

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Tags: afinitor, Calithera Bioscience, CB-839, everolimus, kidney cancer, News, precision medicine, Renal Cancer, renal cell carcinoma


May 24th, 2016

Lenvima® Approved for Kidney Cancer

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The United States Food and Drug Administration (FDA) has approved Lenvima® (lenvatinib) for the treatment of kidney cancer. The approval is for patients with advanced renal cell carcinoma who have received at least one prior therapy with an anti-angiogenic agent, and is to be used in combination with the standard agent Afinitor® (everolimus). Each year […]

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Tags: afinitor, everolimus, fda, General Renal Cancer, kidney cancer, lenvatinib, Lenvima, News, rcc, Renal Cancer, RTK


October 15th, 2015

COMETRIQ® Improves Progression-Free Survival in Kidney Cancer

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According to a recently published study in the New England Journal of Medicine, the targeted agent, COMETRIQ® (cabozantinib), significantly improves the time to cancer progression and survival compared to Afinitor® (everolimus) in patients with advanced kidney cancer whose cancer has progressed following VEGRF-targeted therapy. Each year in the United States, more than 58,000 people are […]

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Tags: afinitor, cabozantinib, COMETRIQ, General Renal Cancer, kidney cancer, News, rcc, Renal Cancer, VEGFR-targeted agents


October 12th, 2015

Opdivo® Improves Survival in Kidney Cancer

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The immunotherapy agent, Opdivo® (nivolumab), improves survival in kidney cancer compared to the standard treatment, Afinitor® (everolimus). These results were recently published in the New England Journal of Medicine. About Renal Cell Carcinoma Each year in the United States, more than 61,000 people are diagnosed with kidney cancer. The most common type of kidney cancer […]

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Tags: afinitor, kidney cancer, metastatic, News, opdivo, rcc, Renal Cancer, renal cell carcinoma


August 10th, 2015

Afinitor® Promising in Neuroendocrine Tumors Originating in Gastrointestinal Tract or Lungs

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The drug Afinitor® (everolimus) is currently be studied in a Phase III clinical trial for patients with nonfunctional neuroendocrine tumors (NET) of the gastrointestinal (GI) tract or lungs. The trial is ongoing, but findings so far are promising: patients treated with Afinitor plus best supportive care appear to live longer without cancer progression than patients […]

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Tags: afinitor, everolimus, Gastric Cancer, General Lung Cancer, Lung Cancer, mtor, NET, neuroendocrine tumors, News, Recurrent Gastric Cancer, Stages III-IV Gastric Cancer


February 5th, 2015

Afinitor® plus Herceptin® and Paclitaxel Effective in Advanced Hormone Receptor-Negative HER2-Positive Breast Cancer

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The combination of Afinitor® (everolimus) plus Herceptin® (trastuzumab) paclitaxel appears effective for patients with advanced HER2-positive breast cancer that is hormone receptor (HR)-negative. These findings were presented at the 2014 San Antonio Breast Cancer Symposium, December 9–13, in San Antonio, Texas. Afinitor is an oral medication that works by inhibiting a protein known as mTOR. […]

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Tags: afinitor, Breast Cancer, herceptin, paclitaxel