Items Tagged ‘all’

September 19th, 2017

Pass it On: It’s Leukemia National Awareness Month

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Leukemia and lymphoma are both hematologic malignancies, meaning that they involve the blood or bone marrow. The American Cancer Society (ACS) estimates that there will be 60,140 new cases of leukemia and 24,400 deaths in 2016. For lymphoma, the ACS estimates that 81,080 new cases and 21,270 deaths will occur in the United States in […]

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Tags: all, AML, CLL, CML, Leukemia, News


September 1st, 2017

FDA Approves First Gene Therapy

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CAR T-cell therapy approved to treat certain children and young adults with B-cell acute lymphoblastic leukemia The U.S. Food and Drug Administration issued a historic action today making the first gene therapy available in the United States, ushering in a new approach to the treatment of cancer and other serious and life-threatening diseases. The FDA […]

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Tags: Acute Lymphoblastic Leukemia, all, cell-based gene therapy, Kymriah, Leukemia, News, tisagenlecleucel


September 1st, 2017

FDA Approves First Gene Therapy

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CAR T-cell therapy approved to treat certain children and young adults with B-cell acute lymphoblastic leukemia The U.S. Food and Drug Administration issued a historic action today making the first gene therapy available in the United States, ushering in a new approach to the treatment of cancer and other serious and life-threatening diseases. The FDA […]

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Tags: Acute Lymphoblastic Leukemia, all, cell-based gene therapy, Kymriah, Leukemia, News, tisagenlecleucel


August 22nd, 2017

The US Food and Drug Administration has approved Besponsa for the Treatment of Refractory B-cell Precursor Acute Lymphoblastic Leukemia

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Besponsa (Inotuzumab ozogamicin) is a targeted therapy designed to bind to B-cell acute lymphoblastic leukemia (ALL) cancer cells that express the CD22 antigen. Acute lymphoblastic leukemia comprises approximately 25% of cancer diagnoses among children under 15 years old and is the most common childhood cancer in the US1. Effective treatment options for patients with r/r […]

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Tags: Acute Lymphoblastic Leukemia, all, B-cell, Besponsa, Inotuzumab, Leukemia, News, ozogamicin, targeted therapy


July 25th, 2017

Chimeric Antigen Receptor (CAR) T-cell Immunotherapy – Crafting a Better T Cell for Immunotherapy

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Novartis CAR-T cell therapy CTL019 unanimously (10-0) recommended for approval by FDA advisory committee to treat pediatric, young adult B-cell Acute Lymphoblastic Leukemia.  CAR-T also shows promise in ALL, CLL, other B-cell malignancies, and other cancers. In CAR T-cell therapy, a patents immune systems T-cells are collected and reprogrammed in the laboratory to recognize and […]

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Tags: all, CAR, chimeric antigen receptor, CLL, News, nhl, Non-Hodgkin's Lymphoma, T-cell Immunotherapy


September 26th, 2016

Rituxan Improves Survival in Young Adults with Acute Lymphoblastic Leukemia

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Acccording to results recently published in the New England Journal of Medicine, young adults with CD20-positive, Philadelphia chromosome  (PH)-negative acute lymphoblastic leukemia (ALL), experience survival benefits with the addition of Rituxan® (rituximab) to standard chemotherapy. ALL in children is a malignant disease, or cancer of the blood, characterized by the rapid uncontrolled growth of abnormal, […]

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Tags: Acute Lymphoblastic Leukemia, all, CD20-positive, Childhood Acute Lymphoblastic Leukemia, children, Leukemia, News, Ph-negative, Philadelphia chromosome (PH)-negative acute lymphoblastic leukemia


September 6th, 2016

Inotuzumab Ozogamicin Improves Progression-Free Survival in Acute Leukemia

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The investigative agent, inotuzumab ozogamicin, significantly improves progression-free survival and 2-year survival rates among patients with acute lymphoblastic leukemia that has stopped responding to prior therapy. These results were recently published in the New England Journal of Medicine. Acute lymphoblastic leukemia (ALL) is an aggressive form of leukemia with limited treatment options once it progresses […]

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Tags: Acute Lymphoblastic Leukemia, all, inotuzumab ozogamicin, Leukemia, lymphoblastic leukemia, News


June 23rd, 2016

Blincyto® Improves Survival in Type of Acute Lymphoblastic Leukemia

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The immunotherapeutic agent, Blincyto (blinatumomab), improves survival compared to standard therapy among patients with B-cell precursor, Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (BCP-ALL) that has stopped responding to prior therapies. These results were presented at a presidential symposium at the 2016 annual European Hematologic Association (EHA) meeting. Acute lymphoblastic leukemia (ALL) is the most aggressive […]

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Tags: 2016, Acute Lymphoblastic Leukemia, all, BCP-ALL, blinatumomab, blincyto, EAH, Leukemia, News, TOWER trial


May 16th, 2016

Hydrocortisone Significantly Improves Neuropsychological Issues in Some Children with Leukemia

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The use of physiologic doses of hydrocortisone appears to significantly improve neuropsychological issues caused by treatment including dexamethasone among children with acute lymphoblastic leukemia. These results were published as an early release article in the Journal of Clinical Oncology. Acute lymphoblastic leukemia (ALL) is a fast-growing form of leukemia, and is a common type of […]

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Tags: Acute Lymphoblastic Leukemia, all, children, cortisol, dexamethasone, hydrocortisone, Leukemia, News


January 19th, 2016

Blincyto® is Promising New Treatment Option for Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia

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Amgen, a biotechnology company, has announced that their immunotherapy drug Blincyto® (blinatumomab) appears promising in the treatment of adults with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). The company announced findings from a Phase 2 trial in a recent press release. Acute lymphoblastic leukemia is a fast-growing cancer of the white blood cells. Relapsed/refractory ALL in […]

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Tags: Acute Lymphoblastic Leukemia, acute lymphoblastic lymphoma, all, blincyto, cd19, immunotherapy, Leukemia, News, Philadelphia chromosome positive


December 31st, 2015

Leukemia and Lymphoma Society Summarizes Major Advances in Treatment of Blood Cancers Presented at American Society of Hematology Meetings

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For the more than one million Americans living with or in remission from a blood cancer, there is more hope than ever for new treatments and even cures—not someday, but today. Clinical findings presented at the 57th American Society of Hematology (ASH) Annual Meeting, in Orlando, December 5-8, made it increasingly clear that new discoveries […]

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Tags: Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, all, AML, ASH, blood cancer, CAR T, Chronic Lymphocytic Leukemia, CLL, fda, Leukemia, Lymphoma


July 23rd, 2015

Blincyto® in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia Appears Promising

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Biotechnology company Amgen has announced that their immunotherapy drug Blincyto® (blinatumomab) appears promising in the treatment of adults with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). The company announced findings from a Phase 2 trial in a recent press release. Acute lymphoblastic leukemia is a fast-growing cancer of the white blood cells. Relapsed/refractory ALL in […]

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Tags: Acute Lymphoblastic Leukemia, all, amgen, blinatumomab, blincyto, Leukemia, News


May 19th, 2015

Blinatumomab

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Class: Biological Therapy Generic Name: Blinatumomab Trade Name: Blincyto® For which conditions is this drug approved? Blincyto is approved for treatment of a certain type of acute lymphoblastic leukemia (ALL): Philadelphia chromosome-negative relapsed or refractory B-cell precursor acute ALL. What is the mechanism of action? Blincyto is a type of drug known as a monoclonal […]

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Tags: Acute Lymphoblastic Leukemia, all, B, Biological Therapy, blincyto, Drug Dictionary


February 18th, 2015

Intravenous Administration of Erwinaze® Approved by FDA

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The U.S. Food and Drug Administration (FDA) recently approved the intravenous administration of Erwinaze® (asparaginase Erwinia chrysanthemi).  Erwinaze is utilized as a component of a multi-agent chemotherapeutic regimen for the treatment of patients with acute lymphoblastic leukemia (ALL) who have developed hypersensitivity to E. coli-derived asparaginase.1 Administration of Erwinaze through an intravenous infusion provides patients with hypersensitivity […]

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Tags: Acute Lymphoblastic Leukemia, all, asparaginase, asparaginase Erwinia chrysanthemi, Erwinaze, FDA approval, Leukemia, leukemia treatment, News


October 27th, 2014

CD19-Directed CAR T Cells Effective in Management of Relapsed/Refractory Acute Lymphoblastic Leukemia

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In a study recently published in The New England Journal of Medicine, doctors have reported achieving sustained remissions in children and adults with relapsed/refractory acute lymphoblastic leukemia (ALL) using CD19-targeted chimeric antigen receptor (CAR)-modified T cells. Acute lymphoblastic lymphoma (ALL) is a fast-growing cancer of the white blood cells. Relapsed/refractory ALL in adults has a […]

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Tags: Acute Lymphoblastic Leukemia, all, CAR T, CD-19, Leukemia, News