Items Tagged ‘Melanoma’

May 7, 2018

FDA Approves Tafinlar® + Mekinist® for Adjuvant Treatment of BRAF V600-mutant Stage III Melanoma

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CancerConnect News: The US Food and Drug Administration (FDA) has approved Tafinlar® (dabrafenib) in combination with Mekinist® (trametinib) for the adjuvant treatment of patients with stage III melanoma with BRAF V600E or V600K mutations, as detected by an FDA-approved test.1 About Melanoma  Stage III melanoma includes cancers of any thickness that have spread to the […]

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Tags: adjuvant treatment, BRAF V600E, dabrafenib, mekinist, Melanoma, News, precision cancer medicines, stage III, tafinlar, trametinib, V600K mutations


April 5, 2018

Tafinlar® + Mekinist® Demonstrates Long Term Survival Benefit for BRAF Mutation-Positive Metastatic Melanoma

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CancerConnect News: Metastatic melanoma patients with the BRAF V600 mutation treated with the combination of Tafinlar® (dabrafenib) + Mekinist® (trametinib) can experience long term cancer free survival according to results presented at the 53rdAnnual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago.1 About Melanoma  Metastatic melanoma refers to skin cancer that has spread from […]

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Tags: BRAF 600, Mekinist rametinib, Melanoma, Metastatic melanoma treatment, News, Precision Cancer Medicine, Skin Cancer, Tafinlar (dabrafenib)


January 15, 2018

Keytruda Significantly Improved Recurrence-Free Survival in Patients with Stage 3 Melanoma

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CancerConnect News:  The European Organisation for Research and Treatment of Cancer (EORTC), today announced that the phase 3 EORTC1325/KEYNOTE-054 trial investigating Keytruda (pembrolizumab), an anti-PD-1 precision immunotherapy for surgically resected high-risk melanoma, met the primary endpoint of improving recurrence-free survival. Adjuvant Therapy in Melanoma Melanoma is separated into five staging categories (stages 0-4).  Stage III […]

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Tags: Melanoma, News


January 12, 2018

Combining T-VEC Herpes Virus With Keytruda Immunotherapy Shows Promise for Treating Advanced Melanoma

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CancerConnect News: UCLA scientists have developed a potential new treatment for melanoma that has shown promising early clinical results.  In a two-year UCLA-led study, nearly two-thirds of people with advanced melanoma responded positively to a treatment that combines the immunotherapy drug keytruda (pembrolizumab) with a herpes virus called T-VEC (talimogene laherpareovec). Researchers found that the […]

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Tags: immunotherapy, keytruda, Melanoma, News, Precision Cancer Medicine, T-VEC, targeted therapy


January 9, 2018

FDA Approves Opdivo for Adjuvant Treatment of Melanoma

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CancerConnect News: The United States Food and Drug Administration granted regular approval to the anti-PD1 monoclonal antibody, Opdivo (nivolumab) for the adjuvant treatment of patients with melanoma with involvement of lymph nodes or in patients with metastatic disease who have undergone complete resection. Opdivo was previously approved for the treatment of patients with unresectable or […]

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Tags: malignant melanoma, Melanoma, News, nibolumab, opdivo, Precision Cancer Medicine, Yervoy


January 8, 2018

Ulixertinib A First-in-class ERK Inhibitor Shows Early Efficacy in Patients With Advanced Cancers

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CancerConnect News: The novel ERK1/2 kinase inhibitor ulixertinib displayed an acceptable safety profile and had clinical activity in patients whose cancers had mutations in the MAPK cell-signaling pathway, according to data from a recent phase 1 clinical trial.  Based on data from this trial, ulixertinib has received the U.S. Food and Drug Administration’s Fast Track […]

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Tags: Colon Cancer, ERK inhibitor, Lung Cancer, MAPK/ERK, Melanoma, News, Precision Cancer Medicine, targeted therapy, ulixertinib


September 28, 2017

Opdivo Proves Superior to Yervoy for Adjuvant Treatment of Stage III-IV Melanoma

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Adjuvant treatment with the immunotherapy drug Opdivo (nivolumab) is superior to Yervoy (ipilimumab) for the management of stage IIIb/c or stage IV melanoma following complete surgical resection. These important results were presented at the European Society for Medical Oncology and published simultaneously in the New England Journal of Medicine. There remains an unmet need for […]

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Tags: immunotherapy, ipilimumab, Melanoma, News, nivolumab, opdivo, Precision Cancer Medicine, Yervoy


July 2, 2013

Investigational Melanoma Drug Shrinks Tumors in Phase III Trial

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In a Phase III clinical trial, the investigational drug T-VEC (talimogene laherparepvec) produced durable responses in people with advanced melanoma.  These results were presented at the 2013 Annual Meeting of the American Society of Clinical Oncology (ASCO). Of the more than one million new diagnoses of skin cancer each year, roughly 76,000 involve melanoma. More […]

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Tags: Melanoma, Stage III Melanoma, Stage IV Melanoma


July 1, 2013

Anti-PD-1 Drugs Promising for Advanced Melanoma

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In Phase I clinical trials, investigational drugs that target a protein known as PD-1 are showing promise for the treatment of advanced melanoma. Results from two of the trials were presented at the 2013 Annual Meeting of the American Society of Clinical Oncology and also published in the New England Journal of Medicine. Of the more […]

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Tags: Melanoma, Stage III Melanoma, Stage IV Melanoma


June 26, 2013

Selumetinib Active Against Melanoma of the Eye

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In a Phase II clinical trial, the investigational targeted drug selumetinib resulted in tumor shrinkage in half of patients with advanced melanoma of the eye. These results were presented at the 2013 Annual Meeting of the American Society of Clinical Oncology. Melanoma of the eye—also known as uveal melanoma—is a rare cancer that affects approximately […]

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Tags: Melanoma, Stage IV Melanoma


May 6, 2011

Many Young Women Continue to Tan

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According to a survey by the American Academy of Dermatology, use of tanning beds remains a common practice among young, white women. Intentional outdoor tanning was also widely reported. Sun exposure has long been linked with skin cancer, and a growing body of evidence indicates that tanning beds also increase risk. Exposure to sunlamps or […]

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Tags: General Skin Cancer, Health and Wellness, Melanoma, Screening/Prevention Melanoma, Skin Cancer


March 18, 2009

Melanoma Overview

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Overview Malignant melanoma is predominantly a disease of the skin, but may in rare instances occur at other sites, including the mucous membranes (vulva, vagina, lip, throat, esophagus and perianal region), as well as in the eye (uvea and retina). Melanoma arises from melanocytes, which are cells located in the upper layer of the skin […]

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Tags: Melanoma


February 6, 2009

What Every Woman Should Know About Cancer Screening

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By Jennifer Maxon, RN Over the past several decades, long-term cancer survival rates have been on the rise.1 These improved outcomes are largely credited to screening measures for certain types of cancers. In general, cancer that can be detected and treated in its earliest stages, prior to any spread—and often prior to any symptoms—is associated […]

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Tags: Breast Cancer, Cervical Cancer, Colon Cancer, Melanoma, Skin Cancer


February 6, 2009

Cancer Vaccines: Stimulating the Immune System to Attack Cancer

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As the age of personalized medicine approaches, the look and feel of cancer treatment may change dramatically. What if, rather than receiving one-size-fits all anticancer drugs, patients were treated with specially formulated treatments made to target their own cancer cells? What if patient’s own cancer and immune cells were actually used to develop a treatment […]

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Tags: Breast Cancer, Lung Cancer, Melanoma, Prostate Cancer, Skin Cancer


February 6, 2009

Understanding Your Melanoma Pathology Report

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If you’ve been diagnosed with malignant melanoma, the most serious form of skin cancer, your physician has made this diagnosis by removing (with a biopsy) the cancerous area on your skin and examining it under a microscope. Following this examination, you’ll receive a pathology report, which will describe your physician’s findings, including stage of disease […]

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Tags: Melanoma