Items Tagged ‘News’

June 26th, 2017

Shorter Duration Chemotherapy Possible for Early Stage Colon Cancer

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Many colon cancer patients can cut their chemotherapy regimen in half, improving their quality of life and reducing their chances of having debilitating side effects, according to the results of a major study released at the American Society of Clinical Oncology’s annual meeting. The goal of the study was to determine whether a three-month course of […]

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Tags: Chemotherapy, Colon Cancer, colon cnacer, early stage III, News


June 26th, 2017

FDA grants regular approval to dabrafenib and trametinib combination for metastatic NSCLC with BRAF V600E mutation

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The U.S. Food and Drug Administration granted regular approvals to Tafinlar® (dabrafenib) and Mekinist® (trametinib) administered in combination for patients with metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation as detected by an FDA-approved test. These are the first FDA approvals specifically for treatment of patients with BRAF V600E mutation-positive metastatic NSCLC. The […]

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Tags: dabrafenib, Lung Cancer, Lung Cancer - Non-Small Cell, mekinist, News, non-small cell lung cancer, precision cancer medicines, tafinlar, targeted therapy, trametinib


June 22nd, 2017

Immunotherapy with Checkpoint Inhibitor Durvalumab Show Promise in Triple Negative Breast Cancer

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Doctors from Yale Cancer Center presented new data at the American Society of Clinical Oncology meeting on the impact of combining the immune checkpoint inhibitor (durvalumab/MEDI4736) with chemotherapy as preoperative treatment for early stage triple negative breast cancer (TNBC).  Overall patients with TNBC achieved a 71% pathologic complete response to the combination treatment in the […]

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Tags: Breast Cancer, checkpoint inhibitor, durvalumab, immunotherapy, News, precision medicine, Triple Negative Breast Cancer


June 20th, 2017

Precision Therapy Enasidenib Effective in Treating Acute Myeloid Leukemia

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According to early clinical trial results published in the journal Blood, some patients with relapsed or treatment-resistant acute myeloid leukemia may achieve remission with an experimental targeted therapy. AML is the most lethal of the blood cancers, which together are the third leading cause of cancer deaths in the U.S.; AML is responsible for more […]

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Tags: 2016, Acute Myeloid Leukemia, AML, asco, blood cancer, COMFORT 1, Enasidenib, IDH2 gene, jakafi, Leukemia, myelofibrosis, News


June 19th, 2017

FDA Fast Track Designation Granted To CB-839 For Treatment Of Patients With Renal Cell Carcinoma

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The U.S. Food and Drug Administration (FDA) has granted Fast Track designation to CB-839 in combination with afinitor® (everolimus), for the treatment of patients with metastatic renal cell carcinoma who have received 2 or more prior lines of therapy.  CB-839 is a first-in-class, oral, selective, potent inhibitor of glutaminase being evaluated in Phase 1/2 clinical […]

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Tags: afinitor, Calithera Bioscience, CB-839, everolimus, kidney cancer, News, precision medicine, Renal Cancer, renal cell carcinoma


June 15th, 2017

With Nearly Three Years of Follow-Up, Keytruda® Continues to have Improved Survival Benefit Compared to Yervoy® in Advanced Melanoma

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Keytruda® (pembrolizumab) continues to outperform Yervoy® (ipilimumab) as initial treatment of patients with advanced melanoma. Updated results of the KEYNOTE 006 trial presented at the 2017 annual meeting of the American Society of Clinical Oncology (ASCO) report that Keytruda is now associated with a 30% improvement in survival when used as initial treatment for advanced […]

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Tags: checkpoint inhibitor, immunotherapy, ipilimumab, KEYNOTE-006, keytruda, Melanoma, News, PD-1, pembrolizumab, precison medicine, Yervoy


June 14th, 2017

Sprycel Effective for Treatment of Pediatric Chronic Myeloid Leukemia

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In 2002, the FDA approved the drug Gleevec (imatinib) as a first-line therapy for adults with chronic myeloid leukemia (CML) caused by the fusion gene BCR-ABL, known as the Philadelphia chromosome. The approval dramatically extended the lives of patients with the condition and, in many ways, ushered in the era of molecularly-targeted treatments against cancer. […]

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Tags: BCR-ABL, Chronic Myeloid Leukemia, CML, dasatinib), Gleevec, imatinib, Leukemia, News, Philadelphia chromosome Sprycel


June 12th, 2017

Alecensa Superior to Xalkori in Treatment of Lung Cancer

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Alecensa (alectinib) halted the spread of lung cancer for a median of 15 months longer than treatment with rival Xalkori (crizotinib) with fewer side effects, according to trial results presented at the 2017 American Society of Clinical Oncology annual meeting in Chicago. Both drugs are designed to treat advanced non-small cell lung cancer (NSCLC) in […]

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Tags: Alecensa, alectinib, ALK gene, ALK-positive NSCLC, crizotinib, Lung Cancer, Lung Cancer - Non-Small Cell, News, nsclc, precision medicine, xalkori


June 9th, 2017

FDA Expands use of Zykadia® in First-Line ALK-Positive Non-Small Cell Lung Cancer

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The US Food and Drug Administration (FDA) approved the expanded use of Zykadia® (ceritinib) to include the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose cancers are anaplastic lymphoma kinase (ALK)-positive, as detected by an FDA-approved test. About Zykadia Zykadia is an oral, selective inhibitor of ALK, a gene that can fuse […]

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Tags: ALK-Positive Non-Small Cell Lung Cancer, ceritinib, Lung Cancer, News, precision medicine, Zykadia


June 9th, 2017

Shows Improved Outcomes with Addition of Keytruda® in Triple Negative High-Risk Breast Cancer

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The results from the I-SPY 2 TRIAL investigating Keyytruda (pembrolizumab), in combination with standard therapy as a pre-operative (neoadjuvant) treatment for patients with locally advanced breast cancer were released at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.  The estimated pathologic complete response (pCR) rate increased nearly threefold in patients with triple-negative […]

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Tags: Breast Cancer, checkpoint inhibitor, keytruda, News, opdivo, PD-1, precision medicine, Triple negative Breast Cancer (TNBC), Yervoy


June 7th, 2017

Abiraterone Delays Metastatic Prostate Cancer Growth by 18 Months, Extends Survival

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Adding Zytiga (abiraterone acetate) plus prednisone to standard hormonal therapy for men with newly diagnosed, metastatic prostate cancer lowers the chance of death by 38%, and more than doubled the median time until the cancer worsened, from 14.8 months to 33 months according to the results of a clinical study featured at the 2017 American […]

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Tags: abiraterone, hormone refractory, metastatic prostate cancer, News, Prostate Cancer, zytiga


June 6th, 2017

Targeted Therapies Show Initial Effectiveness in Subset of Papillary Thyroid Cancer

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Two immunotherapy drugs currently approved by the U.S. Food and Drug Administration (FDA) for the treatment of melanoma also show promise for treating a rare but aggressive form of papillary thyroid cancer. Up to 44 percent of papillary thyroid cancer patients have a B-raf mutation that can be specifically targeted by existing cancer drugs. The […]

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Tags: B-raf mutations, mekinist, News, papillary thyroid cancer, precision medicine, tafinlar, targeted therapy, Thyroid Cancer


June 5th, 2017

Personalized Cell Therapy Combined with Imbruvica Achieves Complete Remission in High Percentage of Chronic Lymphocytic Leukemia Patients

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Combining the kinase inhibitor Imbruvica (ibrutinib) with an investigational personalized cellular therapy known as CTL119 can lead to complete remission in patients with high-risk chronic lymphocytic leukemia (CLL), according to new research from the Perelman School of Medicine at the University of Pennsylvania and Penn’s Abramson Cancer Center (ACC). The team will present the results from its pilot study […]

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Tags: Chronic Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia, CTL119, ibrutinib, kinase inhibitor, Leukemia, News, Personalized Cell Therapy, personalized cellular therapy


June 2nd, 2017

Radiation Therapy can Enhance Effectiveness of Immunotherapy in People With Advanced Lung Cancer

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UCLA RESEARCH ALERT FINDINGS A new study by UCLA scientists has found that the breakthrough immunotherapy drug Keytruda (pembrolizumb)  can be more effective in improving survival in people with non-small cell lung cancer (NSCLC) if they have previously received radiation therapy, compared to those without a history of radiation treatment. The findings are important as […]

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Tags: immunotherapy, Keyturda, Lung Cancer, Lung Cancer - Non-Small Cell, NCSLC, News, PD-1, pembrolizumb, radiation


May 31st, 2017

FDA Approves First-of-its-kind Kisqali® Femara® Co-Pack For Initial Treatment Of HR+/HER2- Advanced or Metastatic Breast Cancer

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The US Food and Drug Administration (FDA) has approved the Kisqali ®Femara ® Co-Pack (ribociclib tablets; letrozole tablets) for the treatment of hormone receptor-positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced or metastatic breast cancer in postmenopausal women 1. The Kisqali-Femara Co-Pack is the first, and only currently available, combination pack with two prescription products in advanced breast […]

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Tags: Advanced Metastatic Breast Cancer, Breast Cancer, HER2 neu negative, HR+, Kisqali® Femara®, News