The Mao lab in the Cellular and Molecular Oncology research program at the University of New Mexico Comprehensive Cancer Center (UNMCCC) is seeking highly motivated postdoctoral researchers to investigate the mechanisms of DNA excision repair and its impact on cancer mutations. The Mao lab has developed several novel genome-wide DNA damage mapping methods. We will use these cutting-edge technologies to characterize DNA damage distribution and excision repair kinetics across the genome. Current projects focus on the molecular mechanism by which transcription initiation factor TFIIH, elongation factor Spt4/5, and histone H2B ubiquitylation regulate DNA repair upon DNA damage-induced RNA polymerase stalling. We are also interested in understanding how excision repair contributes to drug resistance associated with alkylating agents.
The University of New Mexico Comprehensive Cancer Center is the Official Cancer Center of New Mexico and the only National Cancer Institute-designated Cancer Center in a 500-mile radius. One of the premier cancer centers nationwide, the UNM CCC has more than 125 board-certified oncology physicians, forming New Mexico’s largest cancer care team. It treats about 60 percent of adults and virtually all the children in New Mexico diagnosed with cancer — more than 10,000 people— from every county in the state in more than 135,000 clinic visits each year. Through its partnership with the New Mexico Cancer Care Alliance, an “exemplary national model for cancer health care delivery,” the UNM CCC offers access to more than 175 clinical trials to New Mexicans in every part of the state. Annual research funding of almost $60 million supports the UNM CCC’s 130 cancer scientists. Working with partners at Los Alamos and Sandia National Laboratories, Lovelace Respiratory Research Institute, and New Mexico State University, they have developed new diagnostics and drugs for leukemia, breast cancer, ovarian cancer, prostate cancer, liver and pancreatic cancer, brain cancer, and melanoma. Learn more at www.cancer.unm.edu
Ph.D. in Biochemistry, Molecular Biology, Cell Biology or Genetics. Individuals with a strong background in genomics, DNA repair, epigenetics and/or chromatin biology are encouraged to apply. Prior experiences in DNA repair, mammalian cell culture and genetic manipulation, and NGS library preparation are highly desirable.
Send a CV, including a list of three references to Amanda G Leigh (ALeigh@salud.unm.edu) using “application for a postdoctoral researcher position” on the subject line.