Santa Fe Opera House. Photo: Robert Reck
Click on each date below for the day's agenda, or download the final agenda.
| 13:00-17:00 | Registration |
| 18:00 | Welcome Reception |
| 19:30 | Opening Comments Organizing Committee: Alan Tomkinson, Vilhelm Bohr, David Wilson III |
| 19:45 | Keynote Lecture I: Oxidative genome damage and repair: Ubiquity, complexity and pathological implications Sankar Mitra, Radiation Oncology and Cancer Center, and Methodist Research Institute, Houston, Texas, USA |
| 20:30 | Questions |
| 20:45 | Keynote Lecture II: The influence of DNA repair on biological responses to alkylation and inflammation Leona Samson, Department of Biological Engineering, Massachusetts Institute of Technology, Boston, Massachusetts, USA |
| 21:30 | Questions |
| 21:45 | Adjourn (set-up posters) |
| 08:00 | Breakfast |
| Session I: | Repair of Endogenous DNA Damage Chair: Hans E. Krokan |
| 09:00 | Introduction to Sessions I / II Hans E. Krokan, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway |
| 09:15 | Mechanisms of ribonucleotide repair in prokaryotes Roger Woodgate Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, NIH, Rockville, Maryland, USA |
| 09:40 | BER pathways coordinating repair of endogenous oxidative DNA lesions Bruce Demple, Department of Pharmacological Sciences, Stony Brook University, School of Medicine, Stony Brook, New York, USA |
| 10:05 | Crosstalk mechanism between base excision repair and mismatch repair in causing DNA instability at trinucleotide repeats Cynthia T. McMurray, Lawrence Berkeley National Laboratory, Berkeley, California, USA |
| 10:30 - 11:00 | Break |
| Session II: | Integration of DNA Repair in the DNA Damage Response Chair: Hans E. Krokan |
| 11:00 | Regulation of base excision repair in response to genotoxic stress Paul W. Doetsch, Emory University School of Medicine, Atlanta, Georgia, USA |
| 11:25 | Mechanisms regulating BER protein stability and pathway choice Robert W. Sobol, Departments of Pharmacology & Chemical Biology and Human Genetics, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA |
| 11:50 | DNA damage recognition and signaling Grigory Dianov, Gray Institute for Radiation Oncology & Biology, University of Oxford, Oxford, United Kingdom |
| 12:15 - 13:15 | Lunch |
| Session III: | Endogenous Damage in Human Disease Chair: Samuel H. Wilson |
| 13:15 | Introduction to Sessions III / IV Samuel H. Wilson, Laboratory of Structural Biology, National Institutes of Health-NIEHS, Research Triangle Park, North Carolina, USA |
| 13:30 | Dynamics of DNA and RNA modifications; role in disease Arne Klungland, Oslo University Hospital, Rikshospitalet Institute of Medical Microbiology, Oslo, Norway |
| 13:55 | Repair of oxidative damage and repeat instability Margherita Bignami, Department of Environment and Primary Prevention, Istituto Superiore di Sanità, Rome, Italy |
| 14:20 | Autoimmune phenotypes resulting from endogenous DNA damage Joann Sweasy, Departments of Therapeutic Radiology and Genetics, Yale University School of Medicine, New Haven, Connecticut, USA |
| 14:45 - 15:15 | Break |
| Session IV: | Structural Biology of the DNA Damage Response Chair: Samuel H. Wilson |
| 15:15 | Visualizing DNA repair enzymes encountering free radical DNA lesions Sylvie Doublié, Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont, USA |
| 15:40 | Mechanisms of poly(ADP-ribose) glycohydrolysis Ivan Ahel, Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom |
| 15:55 | Structural biology of stress response complexes controlling biological outcomes John A. Tainer, Lawrence Berkeley National Lab, Skaggs Institute for Chemical Biology, & The Scripps Research Institute, La Jolla, California, USA |
| 16:30 | Poster Session |
| 18:45 | Dinner |
| Session V: | Repair of DNA Strand Breaks Chair: Alexander Buerkle |
| 20:00 | Introduction to Session V Alexander Buerkle, Department of Biology, University of Konstanz, Konstanz, Germany |
| 20:15 | Poly(ADP-ribosyl)ation and genome integrity Valerie Schreiber, IREBS-CNRS-University of Strasbourg, LabEx Medalis, Illkirch, France |
| 20:40 | Structure and Function of the BRCA2 Tumour Suppressor Stephen West, London Research Institute, South Mimms, United Kingdom |
| 08:00 - 09:00 | Breakfast |
| Session VI: | Endogenous DNA Damage, Mutation and Cancer Chair: Eugenia Dogliotti |
| 09:00 | Introduction to Sessions VI / VII Eugenia Dogliotti, Department of Environment and Primary Prevention, Istituto Superiore di Sanità, Rome, Italy |
| 09:15 | Single-cell genomics in mutation analysis Jan Vijg, Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA |
| 09:40 | APOBEC3 proteins, DNA uracil and cancer mutagenesis Reuben S. Harris, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA |
| 10:05 | Checkpoint mediated mechanisms controlling genome integrity Marco Foiani, FIRC Institute of Molecular Oncology & University of Milan, Milan, Italy |
| 10:30 | Break |
| Session VII: | Nucleotide Excision Repair, Cross-link Repair and Transcription-Coupled Repair Chair: Eugenia Dogliotti |
| 11:00 | Regulation of the nuclease activity of ERCC1-XPF in various DNA repair pathways Orlando Scharer, Department of Pharmacological Sciences and Department of Chemistry, Stony Brook University, Stony Brook, NY, Regulation of the nuclease activity of ERCC1-XPF in various DNA repair pathways |
| 11:25 | Mechanisms that target Cockayne syndrome B protein for transcription regulation and stress response Hua-Ying Fan, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA |
| 11:50 | Regulation of transcription-coupled DNA repair Wim Vermeulen, Department of Genetics, Erasmus Medical Center, Rotterdam, Netherlands |
| 12:15 | Lunch |
| 08:00 - 09:00 | Breakfast |
| Session VIII: | DNA Damage, Repair and Aging Chair: Vilhelm A. Bohr |
| 09:00 | Introduction to Sessions VIII / IX Vilhelm A. Bohr, Laboratory of Molecular Gerontology, National Institute on Aging, IRP, NIH, Baltimore, Maryland, USA |
| 09:15 | New pathways contributing to genomic instability in progeria Susana Gonzalo, Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri, USA |
| 09:40 | DNA damage as a driver of accelerated and normal aging Laura Niedernhofer, Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, Florida, USA |
| 10:05 | SIRT6 is a regulator of DNA double strand break repair Vera Gorbunova, Department of Biology, University of Rochester, Rochester, New York, USA |
| 10:30 | Break |
| Session IX: | Session IX: DNA Repair in Neuronal Cells Chair: Vilhelm A. Bohr |
| 11:00 | Base excision repair of oxidative damage in brain Magnar Bjørås, Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway |
| 11:25 | Polynucleotide kinase/phosphatase is critical for genome stability during neurogenesis Peter J. McKinnon, Department of Genetics, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA |
| 11:50 | Endogenous DNA strand breakage and disease Keith W. Caldecott, Genome Damage and Stability Centre, University of Sussex, Brighton, United Kingdom |
| 12:15 - 13:15 | Lunch |
| Session X: | Therapeutic Targets and Disease Treatment Strategies Chair: Srinivasan Madhusudan |
| 13:15 | Introduction to Session X Srinivasan Madhusudan, Division of Oncology, School of Medicine, University of Nottingham, Nottingham University Hospitals, Nottingham, United Kingdom |
| 13:30 | Targeting MTH1 for treatment of cancer Thomas Helleday, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden |
| 13:55 | Presentation Title TBN |
| 14:20 | Exploiting dysregulated DNA damage response for cancer therapy Nicola J. Curtin, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom |
| 14:45 | A roadmap for translating discoveries in DNA damage repair into clinical benefit for patients: Case study with PARP inhibitors Keith M. Wilcoxen, TESARO, Inc., Waltham, Massachusetts, USA |
| 15:10 | Break |
| 15:45 | Short Presentations Eight 15-minute presentations selected from abstracts (2 hours) |
| 18:00 | Keynote Lecture III: Mechanisms in human mismatch repair Paul Modrich, HHMI & Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, USA |
| 18:45 | Questions |
| 19:00 | Adjourn |
| 19:30 | Banquet |
| 08:00 | Breakfast and Depart |
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